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MetabolomicsMethionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling

The folate and methionine cycles (Met-C) are regulated by vitamin B12 (B12), obtained exclusively from diet and microbiota. Met-C supports amino acid, nucleotide, and lipid biosynthesis and provides one-carbon moieties for methylation reactions. While B12 deficiency and polymorphisms in Met-C gen...

2025-07-05 | MTBLS12457 | MetaboLights
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells treated with a CDK inhibitor
A genomics-based approach to identify pharmacodynamic biomarkers was used for a CDK (cyclin-dependent kinase) inhibitory drug. R547 is a potent CDK inhibitor with a potent anti-proliferative effect at pharmacologically relevant doses, and is currently in Phase I clinical trials. Utilizing preclinic...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-15389 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis reveals Flg22 regulates MAP kinase 6 interaction with an ethylene response factor substrate via ethylene
Despite their importance, plant MAP kinase targets are still poorly elucidated. Here, the specific in vivo interaction of an ethylene response factor (ERF104) with the Arabidopsis MAP kinase, MPK6, is shown by fluorescence resonance energy transfer. The interaction, which is lost within minutes afte...
ORGANISM(S): Arabidopsis thaliana 
2009-05-27 | E-GEOD-11807 | biostudies-arrayexpress
TranscriptomicsAT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. pombe reveals Cyclin dependent kinase inhibits re-initiation of a normal S-phase program during G2
To achieve faithful replication of the genome once in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. We have investigated the block to re-replication during G2 in fission yeast. The DNA synthesis that occurs when G2/M cyclin d...
ORGANISM(S): Schizosaccharomyces pombe 
2009-05-13 | E-MTAB-105 | biostudies-arrayexpress
TranscriptomicsThe investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell cycle progression in mouse bladder cancer cells in vitro and in vivo
PURPOSE: Despite over 70,000 new cases of bladder cancer in the United States annually, patients with advanced disease have a poor prognosis due to limited treatment modalities. We evaluate the role of Aurora A, identified as an upregulated candidate molecule in bladder cancer, in regulating bladde...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-42089 | biostudies-arrayexpress
Models,MultiomicsCell Cycle Transcription by Coupled CDK and Network Oscillators
A significant fraction of the Saccharomyces cerevisiae genome is transcribed periodically during the cell division cycle, indicating that properly timed gene expression is important for regulating cell-cycle events. Genomic analyses of the localization and expression dynamics of transcription factor...
2681 | Cell Collective
TranscriptomicsTranscriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study
Microarray analysis of transcriptional changes in biopsies of solid tumors from patients treated in a Phase I study with the Cdk inhibitor PHA-793887. 7 patient biopsies pre- and post-treatment in dye swap. Tumors are of different origins, and are described in the accompanying manuscript.
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-18553 | biostudies-arrayexpress
TranscriptomicsKinase activity profiling of human locally advanced rectal cancer samples
Locally advanced rectal cancer characterized by multiplex kinase activity profiling
ORGANISM(S): Homo sapiens 
2010-08-05 | E-TABM-913 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human non-activated MM6 cells with cyclin T1 knockdown
Cyclin T1-dependent genes in LPS-activated MM6 cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II ...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10738 | biostudies-arrayexpress
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