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TranscriptomicsMouse cells cyclophosphamide treated vs untreated
This SuperSeries is composed of the following subset Series: GSE27421: Mouse bone marrow cyclophosphamide treated vs untreated GSE27422: Mouse peripheral blood leukocytes cyclophosphamide treated vs untreated GSE27423: Mouse spleen cyclophosphamide treated vs untreated Refer to individual Series
ORGANISM(S): Mus musculus 
2011-04-27 | E-GEOD-27440 | biostudies-arrayexpress
TranscriptomicsMouse spleen cyclophosphamide treated vs untreated
Analysis the effect of cyclophosphamide on splenocytes gene expression. Certain chemotherapeutic drugs such as cyclophosphamide can enhance the antitumor efficacy of immunotherapy because of their capacity to modulate innate and adaptive immunity. Indeed, it has been argued that this capacity may be...
ORGANISM(S): Mus musculus 
2011-04-27 | E-GEOD-27423 | biostudies-arrayexpress
TranscriptomicsMouse bone marrow cyclophosphamide treated vs untreated
Analysis the effect of cyclophosphamide on bone marrow gene expression. Certain chemotherapeutic drugs such as cyclophosphamide can enhance the antitumor efficacy of immunotherapy because of their capacity to modulate innate and adaptive immunity. Indeed, it has been argued that this capacity may be...
ORGANISM(S): Mus musculus 
2011-04-27 | E-GEOD-27421 | biostudies-arrayexpress
TranscriptomicsMouse peripheral blood leukocytes cyclophosphamide treated vs untreated
Analysis of the effect of cyclophosphamide on peripheral blood leukocyte gene expression. Certain chemotherapeutic drugs such as cyclophosphamide can enhance the antitumor efficacy of immunotherapy because of their capacity to modulate innate and adaptive immunity. Indeed, it has been argued that th...
ORGANISM(S): Mus musculus 
2011-04-27 | E-GEOD-27422 | biostudies-arrayexpress
MetabolomicsUPLC-QE-Orbitrap-MS-Based Metabolomics and Gut Microbiome Analysis to Reveal Codonopsis pilosula (Franch.) Nannf. Extract Improves Cyclophosphamide-Induced Immunosuppression in Mice

Immune system dysfunction leads to recurrent or severe infections, increased susceptibility to concurrent illnesses, and heightened risk of tumors. Current immunomodulators often carry side effects, whereas phytotherapy offers relative stability, making this therapeutic approach worthy of explora...

2026-02-03 | MTBLS13825 | MetaboLights
TranscriptomicsGene expression profiling of the effects of Cyclophosphamide on peripheral blood mononuclear cells
Certain anticancer drugs, particularly cyclophosphamide (CTX), were shown to enhance the antitumor efficacy of immunotherapy through different immunomodulatory mechanisms. A better understanding of the cellular and molecular basis of CTX-mediated immunomodulation is needed to improve the efficacy of...
ORGANISM(S): Homo sapiens 
2013-09-02 | E-GEOD-39324 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of immunogenic actions of metronomic cyclophosphamide treatment: dependence of gene responses on tumor model, mouse host, and drug schedule
RNA-seq analysis was performed using RNA isolated from three tumor models (GL261 glioma, LLC Lewis lung carcinoma, B16F10 melanoma) implanted subcutaneousy in C57BL/6 mice, or in ICR scid mice. Mice were untreated or were treated with cyclophosphamide (CPA) given on a 6-day repeating metronomic sche...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-71491 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of human gene expression in metronomic cyclophosphamide-treated human glioma U251 xenografts implanted in scid mice
Cyclophosphamide (CPA) treatment on a six-day repeating metronomic schedule induces a dramatic, innate immune cell-dependent regression of implanted gliomas. However, little is known about the underlying mechanisms of innate immune cell mobilization and recruitment, or about the role of DNA damage a...
ORGANISM(S): Homo sapiens 
2015-05-04 | E-GEOD-60867 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of mouse gene expression in metronomic cyclophosphamide-treated human glioma U251 xenografts implanted in scid mice
Cyclophosphamide (CPA) treatment on a six-day repeating metronomic schedule induces a dramatic, innate immune cell-dependent regression of implanted gliomas. However, little is known about the underlying mechanisms of innate immune cell mobilization and recruitment, or about the role of DNA damage a...
ORGANISM(S): Homo sapiens 
2015-05-04 | E-GEOD-60866 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of mouse gene expression in metronomic cyclophosphamide-treated rat glioma 9L xenografts implanted in scid mice
Cyclophosphamide (CPA) treatment on a six-day repeating metronomic schedule induces a dramatic, innate immune cell-dependent regression of implanted gliomas. However, little is known about the underlying mechanisms of innate immune cell mobilization and recruitment, or about the role of DNA damage a...
ORGANISM(S): Rattus norvegicus 
2015-05-04 | E-GEOD-60864 | biostudies-arrayexpress
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