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TranscriptomicsImmune cell-specific Cyp11a1 deletion impairs inflammation resolution following LPS-induced acute lung injury in mice
Bulk RNA sequencing was performed on lung tissue from control and immune cell-specific Cyp11a1 conditional knockout (Cyp11a1fl/fl;Vav1Cre) mice following lipopolysaccharide (LPS)-induced acute lung injury. The experiment was designed to characterise genome-wide transcriptional changes associated wit...
ORGANISM(S): Mus musculus 
2026-09-15 | E-MTAB-17666 | biostudies-arrayexpress
TranscriptomicsscRNAseq of Cyp11a1-expressing cells from mouse melanoma model derived tumors
Tumours induce de novo steroidogenesis in immune cells. We wanted to define the gene expression identity of intratumoural steroidogenic immune cells and compare them with the transcriptome with non-steroidogenic cells. Cyp11a1 expression is a faithful biomarker of de novo steroidogenesis (i.e. Cyp11...
ORGANISM(S): Mus musculus 
2020-05-27 | E-MTAB-8509 | biostudies-arrayexpress
Genomicse18.5 pancreas: WT vs Cyp11a1 KO
e18.5 pancreas: WT vs Cyp11a1 KO
PRJNA739748 | ENA
GenomicsscRNAseq of Cyp11a1-expressing cells from mouse melanoma model derived tumors
scRNAseq of Cyp11a1-expressing cells from mouse melanoma model derived tumors
PRJEB35363 | ENA
Transcriptomicse18.5 pancreas: WT vs Cyp11a1 KO
RNA profiling of WT and cyp11a1 KO pancreas at e18.5
ORGANISM(S): Mus musculus 
2021-06-25 | GSE178633 | GEO
TranscriptomicsThe Role of DNMT1 and C/EBPα in the Regulation of CYP11A1 Expression During Syncytialization of Human Placental Trophoblasts
Progesterone synthesized in the placenta is essential for pregnancy maintenance. CYP11A1 is a key enzyme in progesterone synthesis, and its expression increases greatly during trophoblast syncytialization. However, the underlying mechanism remains elusive. Here, we demonstrated that passive demethyl...
ORGANISM(S): Homo sapiens 
2024-08-05 | GSE183700 | GEO
GenomicsThe Role of DNMT1 and C/EBPα in the Regulation of CYP11A1 Expression During Syncytialization of Human Placental Trophoblasts
The Role of DNMT1 and C/EBPα in the Regulation of CYP11A1 Expression During Syncytialization of Human Placental Trophoblasts
PRJNA761707 | ENA
GenomicsThe transcriptome data of primary microglia cells from contrl and over expression CYP11A1 rat's offspring
The transcriptome data of primary microglia cells from contrl and over expression CYP11A1 rat's offspring
PRJNA770899 | ENA
UnknownThe A'-helix of CYP11A1 remodels mitochondrial cristae.
Not available
S-EPMC9386925 | biostudies-literature
GenomicsAttenuation of DNMT1-mediated DNA methylation upregulates CYP11A1 expression in progesterone synthesis during syncytialization of placental trophoblasts
Attenuation of DNMT1-mediated DNA methylation upregulates CYP11A1 expression in progesterone synthesis during syncytialization of placental trophoblasts
PRJNA956922 | ENA
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