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ProteomicsMultiomics approach to decipher pathophysiological mechanisms and therapeutic impact of methionine restriction in cystathionine β-synthase deficient homocystinuria
Background. Cystathionine β-synthase (CBS)-deficient homocystinuria (HCU) is an inherited disorder of sulfur amino acid metabolism with varying severity and organ complications, and a limited knowledge about underlying pathophysiological processes. Here we aimed at getting an in-depth insight into d...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD049417 | Pride
Cystathionine beta-synthase  homocystinuria  methionine restriction  metabolomics  proteomics 
GenomicsCystathionine beta synthase (CBS) Over expression vs PLenti6 Expression Vector Human Bronchial Epithelial Cells (HBEC)
Cystathionine beta synthase (CBS) Over expression vs PLenti6 Expression Vector Human Bronchial Epithelial Cells (HBEC)
PRJNA762118 | ENA
TranscriptomicsEndogenous Elevation of Homocysteine Induces Retinal Neuron Death in the Cystathionine-b-Synthase Mutant Mice
The effects of endogenous elevation of homocysteine on retinal gene expression were screened by microarray analysis, which was performed in triplicate (i.e., three different paired RNA samples) with RNA isolated from neural retinas of cbs+/- HM at 5-weeks after a methionine diet and age-matched wild...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-56458 | biostudies-arrayexpress
UnknownStructural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.
Not available
S-EPMC3000283 | biostudies-literature
ProteomicsNeurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy
Down syndrome (DS) is a genetic condition where the person is born with an extra chromosome 21. DS is associated with accelerated aging; people with DS are prone to age-related neurological conditions including an early-onset Alzheimer’s disease. Using the Dp(17)3Yey/ + mice, which overexpresses a p...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-30 | PXD048079 | Pride
Hydrogen sulfide  bioenergetics  gasotransmitters  proliferation  mitochondria 
TranscriptomicsCystathionine beta synthase (CBS) Over expression vs PLenti6 Expression Vector Human Bronchial Epithelial Cells (HBEC)
Cystathionine Beta Synthase (CBS), an enzyme that utilizes a methionine precursor to generate glutathione (GSSH), has been implicated in the mitigation of ROS production in COPD lung. Additionally, post-translational modification analysis on mouse and human cells treated with cigarette smoke showed ...
ORGANISM(S): Homo sapiens 
2022-06-30 | GSE183858 | GEO
TranscriptomicsBile-inducible membrane protein mediates the bile resistance phenotype of Bifidobacterium breve UCC2003
Bbr_0838 from Bifidobacterium breve UCC2003 encodes a 683 residue membrane protein, that contains a permease domain displaying similarity to transporters belonging to the major facilitator superfamily, as well as a CBS (cystathionine beta synthase) domain. The high level of similarity to bile-efflux...
ORGANISM(S): Bifidobacterium breve UCC2003 
2012-02-20 | E-GEOD-31224 | biostudies-arrayexpress
UnknownCystathionine β-synthase regulates mitochondrial morphogenesis in ovarian cancer.
Not available
S-EPMC6044063 | biostudies-literature
UnknownCystathionine β-synthase deficiency: Of mice and men.
Not available
S-EPMC5526210 | biostudies-literature
UnknownMolecular characterization of a cystathionine beta-synthase gene, CBS1, in Magnaporthe grisea.
Not available
S-EPMC118034 | biostudies-literature
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