Sort   by:  
 Page size 
ProteomicsProteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress, PART 1
Reactive oxygen species (ROS) are increasingly recognised as important regulators of cellular biology through the oxidative modification of protein cysteine residues. Comprehensive identification of redox-regulated proteins and cellular pathways are crucial to understand ROS-mediated events. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-06 | PXD006363 | Pride
Oxidative stress High ph fractionation Proteome Orbitrap hf Ros Mouse kidney tissue fumarate hydratase (fh) deficient Dimethyl labeling Primary immortalised kidney epithelial cells fumarate hydratase (fh) deficient Cysteine oxidation quantitation 
ProteomicsProteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress, PART 2
Reactive oxygen species (ROS) are increasingly recognised as important regulators of cellular biology through the oxidative modification of protein cysteine residues. Comprehensive identification of redox-regulated proteins and cellular pathways are crucial to understand ROS-mediated events. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-06 | PXD006372 | Pride
Oxidative stress High ph fractionation Proteome Orbitrap hf Ros Mouse kidney tissue fumarate hydratase (fh) deficient Dimethyl labeling Primary immortalised kidney epithelial cells fumarate hydratase (fh) deficient Cysteine oxidation quantitation 
ProteomicsProteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress, PART 3
Reactive oxygen species (ROS) are increasingly recognised as important regulators of cellular biology through the oxidative modification of protein cysteine residues. Comprehensive identification of redox-regulated proteins and cellular pathways are crucial to understand ROS-mediated events. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-06 | PXD006373 | Pride
Oxidative stress High ph fractionation Proteome Orbitrap hf Ros Mouse kidney tissue fumarate hydratase (fh) deficient Dimethyl labeling Primary immortalised kidney epithelial cells fumarate hydratase (fh) deficient Cysteine oxidation quantitation 
ProteomicsCysteine-targeted proteomics analysis
The protein cysteine residue is one of the amino acids most susceptible to oxidative modifications, frequently caused by oxidative stress. Several applications have enabled cysteine-targeted proteomics analysis with simultaneous detection and quantitation. In this study, we employed a quantitative a...
ORGANISM(S): Homo sapiens (Human) 
2016-07-18 | PXD004303 | Pride
Hek293t Iodotmt6plex 
UnknownProteome-wide detection and quantitative analysis of irreversible cysteine oxidation using long column UPLC-pSRM.
Not available
S-EPMC3823053 | biostudies-literature
ProteomicsComparative proteomics using iodoTMT to identify changes in protein expression and cysteine oxidation in Leishmania mexicana
Two cell-lines of Leishmania mexicana were investigated using a TMT-based approach; wild-type and an attenuated H-line. Half of each sample was fully reduced and all cysteine residues were labelled with the cysteine-reactive iodoTMT reagent, while the other half was reacted with N-ethylmaleimide to ...
ORGANISM(S): Leishmania mexicana MHOM/GT/2001/U1103 
2018-11-23 | PXD010938 | Pride
Leishmania mexicana Tmt Cysteine oxidation Comparative proteomics 
UnknownAbsolute Quantitation of Tryptophan-Containing Peptides and Amyloid β-Peptide Fragments by Coulometric Mass Spectrometry.
Not available
S-EPMC8925997 | biostudies-literature
ProteomicsMethionine Alkylation as an Approach to Quantify Methionine Oxidation Using Mass Spectrometry
Post-translational oxidation of methionine residues can destabilize proteins or modify their functions. Although levels of methionine oxidation can provide important information regarding the structural integrity and regulation of proteins, their quantitation is often challenging as analytical proce...
ORGANISM(S): Escherichia coli 
2024-02-08 | PXD045497 | Pride
Methionine oxidation  methionine alkylation  proteomics Mass spectrometry (ms) 
ProteomicsClick Chemistry-based Thiol Redox Proteomics Reveals Significant Cysteine Reduction Induced by Chronic Ethanol Consumption
In the U.S., alcohol-associated liver disease (ALD) impacts millions of people and is a major healthcare burden. While the pathology of ALD is unmistakable, the molecular mechanisms underlying ethanol hepatotoxicity are not fully understood. Hepatic ethanol metabolism is intimately linked with alte...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-19 | PXD042070 | Pride
Redox proteomics Proteomics Glutathione Mus musculus Agilent 6550 q-tof Redox Cysteine Thiol Click chemistry Alcohol-associated liver disease 
ProteomicsAcetylation of Proximal Cysteine-Lysine Pairs by Alcohol Metabolism
Alcohol consumption induces hepatocyte damage through complex processes involving oxidative stress and disrupted metabolism. Combined, these factors alter proteomic and epigenetic marks providing a critical opportunity to identify therapeutic targets. Indeed, alcohol-induced protein acetylation is a...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-17 | PXD054686 | Pride
Alcohol-associated liver disease Protein modeling Mass spectrometry Cysteine proteomics Redox Acetylation 
Sort   by:  
 Page size