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MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
MetabolomicsPKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Cells have evolved multiple strategies to survive environmental stress conditions. This includes the formation of membrane-less cytoplasmic ribonucleoprotein structures called stress granules that sequester and protect mRNAs encoding many housekeeping genes. Stress granules are not static biomolecul...
2026-06-16 | MTBLS13923 | MetaboLights
MetabolomicsA local source of insulin in the eye governed by phagocytosis and starvation
Not available
ORGANISM(S): Mus musculus 
ST001897 | MetabolomicsWorkbench
MetabolomicsA Phosphate starvation response gene (psr1-like) is present in Micromonas pusilla and other marine algae and coordinates the metabolic response to phosphate deficiency
Both marine phytoplankton and terrestrial plants have to deal with limited bioavailability of the key life nutrient, phosphate. In freshwater algae and plants, a phosphate starvation response gene (psr1) has been characterized, which encodes for a transcription factor that regulates the metabolic re...
2016-02-01 | MTBLS295 | MetaboLights
TranscriptomicsTranscription profiling of Pseudomonas aeruginosa of the sulfate starvation response
Gene expression in response to changes in sulfur supply was studied in P. aeruginosa E601, a cystic fibrosis isolate that displays mucin sulfatase activity, and in P. aeruginosa PAO1. A large family of genes was found to be upregulated by sulfate limitation in both isolates, encoding sulfatases and ...
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-16 | E-GEOD-8408 | biostudies-arrayexpress
TranscriptomicsExogenous Sulfide Reverses the Alteration of Transcriptional Profiling of the des1-1 Mutant (Arabidopsis thaliana)
Arabidopsis thaliana cells contain different O-acetylserine(thiol)lyase (OASTL) enzymes that catalyze the biosynthesis of cysteine. Recently, we have deeply investigated about one of the minor OASTL-like protein located in the cytosol, named DES1, highlighting some important clues about its metaboli...
ORGANISM(S): Arabidopsis thaliana 
2013-04-25 | E-GEOD-32566 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression after tyrosine or methionine/cysteine deprivation in HeLa cells
Limitation of essential amino acids, such as tyrosine or methionine/cysteine, causes upregulation of exogenous integrated transgene expression in mammalian cells. This phenomenon is mediated by histone acetylation and chromatin remodelling, since histone deacetylase (HDAC) inhibitors reproduce starv...
ORGANISM(S): Homo sapiens 
2012-07-23 | E-GEOD-35323 | biostudies-arrayexpress
ProteomicsGlobal proteomics analysis reveals a role for histone variant H3.3 in the response to starvation
Periodic starvation of animals induces large shifts in metabolism, but may also influence many other cellular systems and can lead to adaption to prolonged starvation conditions. To date, there is limited understanding of how starvation affects gene expression, particularly at the protein level. Her...
ORGANISM(S): Caenorhabditis elegans 
2015-06-17 | PXD001723 | Pride
C. elegans Starvation Histone 
TranscriptomicsE. coli Isoleucine starvation and stringent response network
Transcription profiling of wild type, relA-, and relA-spoT-, crp-, dksA-, rpoS-, lrp- mutant strains of E. coli starved for isoleucine Bacteria comprehensively reorganize their global gene expression when faced with nutrient exhaustion. In Escherichia coli and other free-living bacteria, the alarmo...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2008-04-08 | E-GEOD-11087 | biostudies-arrayexpress
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