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MetabolomicsMetabolic Phenotyping and Strain Characterisation of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Using Rapid Evaporative Ionisation Mass Spectrometry
Rapid evaporative ionisation mass spectrometry (REIMS) is a novel technique for the real-time analysis of biological material. It works by conducting an electrical current through a sample, causing it to rapidly heat and evaporate, with the analyte containing vapour channelled to a mass spectrometer...
2022-01-26 | MTBLS644 | MetaboLights
MetabolomicsMicrobial ecology of nontuberculous mycobacteria (NTM) in cystic fibrosis (CF) sputum
Not available
ORGANISM(S): Homo sapiens 
ST000711 | MetabolomicsWorkbench
TranscriptomicsmiRNA expression profiling in Cystic Fibrosis Airway Epithelium
Cystic fibrosis (CF) is one of the commonest lethal genetic diseases in which the role of microRNAs (miRNAs) has yet to be explored. We hypothesized that unique miRNA expression profiles exist in CF versus non-CF bronchial epithelial cells so the our aim was to investigate whether unique miRNA expre...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19431 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pseuodomonas aeruginosa cystic fibrosis (CF) isolates
To provide a more detailed survey of adaptive changes in the physiology of P. aeruginosa (PA) during long-term infection of the cystic fibrosis (CF) lung, we performed a comparative proteome and transcriptome analysis of a set of isogenic sequential non-mutator and mutator isolates from three select...
ORGANISM(S): Pseudomonas aeruginosa 
2009-06-08 | E-GEOD-10362 | biostudies-arrayexpress
TranscriptomicsGene expression in rectal epithelia of cystic fibrosis patients
Gene expression profiles were recorded from rectal suction specimens of Cystic Fibrosis (CF) patients, carrying the CF-specific D508 mutated CFTR-allele. These profiles were compared with gene expression profiles from rectal suction specimens of non-CF subjects (control). We used Affymetrix GeneChi...
ORGANISM(S): Homo sapiens 
2013-11-28 | E-GEOD-15568 | biostudies-arrayexpress
TranscriptomicsRescue Of Dysfunctional Autophagy By Peptide IDR-1018 Attenuates Hyperinflammatory Phenotype Of Cystic Fibrosis Cells (RNA-seq)
Genome-wide gene expression was measured in peripheral blood mononuclear cells (PBMCs) from patients with cystic fibrosis (CF) after treatment in vitro with the flagellin protein fliC, and/or synthetic peptide IDR-1018 to assess patterns of gene expression. The patterns of gene expression suggest th...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-35394 | biostudies-arrayexpress
TranscriptomicsBurkholderia cepacia complex and cystic fibrosis (CF) patients
This SuperSeries is composed of the following subset Series: GSE28306: Expression data from Burkholderia multivorans cystic fibrosis clinical isolates GSE30402: Hybridization of Burkholderia multivorans D2095 and D2214 genomic DNA Refer to individual Series
ORGANISM(S): Burkholderia multivorans 
2011-08-21 | E-GEOD-30568 | biostudies-arrayexpress
TranscriptomicsAltered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice.
Cystic fibrosis (CF) mouse models exhibit exocrine pancreatic function yet do not develop adipose stores to the levels of non-CF mice. CF mice homozygous for the Cftr mutation (F508del) at 3 weeks (post-weaning) and 6 weeks (young adult) of age had markedly less adipose tissue than non-CF mice. Both...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-33319 | biostudies-arrayexpress
TranscriptomicsPseudomonas aeruginosa lasR mutants in young cystic fibrosis patients
Pseudomonas aeruginosa undergoes genetic change during chronic infection of the airways of cystic fibrosis (CF) patients. One common change is mutation of lasR. LasR is a transcriptional regulator that responds to one of the quorum sensing signals in P. aeruginosa, and regulates acute virulence fa...
ORGANISM(S): Pseudomonas aeruginosa 
2010-06-30 | E-GEOD-5560 | biostudies-arrayexpress
TranscriptomicsReduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung
Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Although bacterial lung infection and the resulting inflammation cause most of the morbidity and mortality, how loss of CFTR first disrupts airway host defen...
ORGANISM(S): Sus scrofa 
2012-03-29 | E-GEOD-36906 | biostudies-arrayexpress
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