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MetabolomicsMetabolomic Profiling of Renal Cyst Fluid in Advanced ADPKD: Insights from Dialysis and Transplantation Cohorts

Background: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by progressive renal cyst formation, often leading to end-stage kidney disease (ESKD). While urinary metabolomics in ADPKD has been extensively studied, the composition of renal cyst fluid, par...

2025-07-07 | MTBLS12372 | MetaboLights
MetabolomicsMetabolic Phenotyping and Strain Characterisation of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Using Rapid Evaporative Ionisation Mass Spectrometry
Rapid evaporative ionisation mass spectrometry (REIMS) is a novel technique for the real-time analysis of biological material. It works by conducting an electrical current through a sample, causing it to rapidly heat and evaporate, with the analyte containing vapour channelled to a mass spectrometer...
2022-01-26 | MTBLS644 | MetaboLights
MetabolomicsAmniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome
Background: Polycystic ovary syndrome is associated with metabolic and hormonal disturbances during pregnancy, but whether these alterations are reflected in the fetal intrauterine exposure environment remains incompletely understood. This study aimed to identify polycystic ovary syndrome-related in...
2026-07-25 | MTBLS14946 | MetaboLights
ProteomicsLC-MS/MS analysis of human thyroid cystic fluid and thyroid cancer cell secreted proteins
Thyroid ultrasound and ultrasound-guided fine-needle aspiration (USG/FNA) biopsy are currently used for diagnosing papillary thyroid carcinoma (PTC), but their detection limit could be improved by combining other biomarkers. To discover novel PTC biomarkers, we herein applied a GeLC-MS/MS strategy t...
ORGANISM(S): Homo sapiens (Human) 
2018-03-21 | PXD007532 | Pride
Human Thyroid cystic fluid Thyroid cancer cell Lc-ms/ms 
ProteomicsProteomics analysis of cystic fluid from human cystic papillary thyroid carcinoma
Here we have performed quantitative and qualitative profiling of the proteome of cystic fluid from human cystic papillary thyroid carcinoma with the aim to identify specific proteins and pathways involved in cystic fluid from human cystic papillary carcinoma, as well as possible diagnostic markers.
ORGANISM(S): Homo sapiens (Human) 
2015-05-20 | PXD000996 | Pride
Cystic fluid Isoelectric focusing Biomarker discovery Proximal fluid Papillary thyroid carcinoma 
ProteomicsThe protein repertoires of hydatid fluid from pulmonary cystic echinococcosis
Echinococcosis is a disease resulting from infection by flatworms of the Echinococcus genus. The vast majority of cystic echinococcosis cases in Southern Brazil are caused by Echinococcus granulosus and Echinococcus ortleppi. Here, we surveyed the protein contents of the hydatid fluid compartment of...
ORGANISM(S): Echinococcus ortleppi Echinococcus granulosus 
2022-04-04 | PXD019314 | Pride
Host-parasite interface Echinococcus ortleppi Hydatid fluid Echinococcus granulosus 
TranscriptomicsTranscription profiling of mouse wild type and pkd1-/- kidney epithelial cells with and without fluid flow
Examining GE profiles in kidney epithelial cells with & without fluid flow
ORGANISM(S): Mus musculus 
2008-01-19 | E-TABM-411 | biostudies-arrayexpress
TranscriptomicsReduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung
Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Although bacterial lung infection and the resulting inflammation cause most of the morbidity and mortality, how loss of CFTR first disrupts airway host defen...
ORGANISM(S): Sus scrofa 
2012-03-29 | E-GEOD-36906 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling in Cystic Fibrosis Airway Epithelium
Cystic fibrosis (CF) is one of the commonest lethal genetic diseases in which the role of microRNAs (miRNAs) has yet to be explored. We hypothesized that unique miRNA expression profiles exist in CF versus non-CF bronchial epithelial cells so the our aim was to investigate whether unique miRNA expre...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19431 | biostudies-arrayexpress
GenomicsHuman cystic fibrosis bronchoalveolar lavage fluid
Human cystic fibrosis bronchoalveolar lavage fluid 16S rDNA sequences
PRJNA1295542 | ENA
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