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ProteomicsA potent cytidine deaminase biodegrader sensitises cancer cells to deoxycytidine analogue-based chemotherapies
Deoxycytidine analogues (dC) are chemotherapy agents used to treat a range of solid and blood cancers. However, their clinical efficacy is often limited by resistance mechanisms. Cytidine deaminase (CDA) plays a key role of this resistance by deaminating dC analogues into inactive metabolites. Altho...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD065390 | Pride
Targeted protein degradation Cytarabine Cytidine deaminase Chemotherapy resistance Single domain antibody Lung cancer Biodegrader Pancreatic cancer Gemcitabine 
UnknownCopy number variation and cytidine analogue cytotoxicity: a genome-wide association approach.
Not available
S-EPMC2894803 | biostudies-literature
UnknownSynthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue.
Not available
S-EPMC5449585 | biostudies-literature
UnknownFluorescence Turn-On Sensing of DNA Duplex Formation by a Tricyclic Cytidine Analogue.
Not available
S-EPMC5352299 | biostudies-literature
UnknownThe effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures.
Not available
S-EPMC5459817 | biostudies-literature
UnknownCytidine deaminase can deaminate fused pyrimidine ribonucleosides.
Not available
S-EPMC8295196 | biostudies-literature
UnknownDevelopment and Comparison of 4-Thiouridine to Cytidine Base Conversion Reaction.
Not available
S-EPMC10905967 | biostudies-literature
TranscriptomicsTranscriptional response to zebularine and mitomycin C (MMC) in wild type and ATR deficient Arabidopsis thaliana plants
Zebularine is a non-methylable cytidine analog that is used in epigenetic and cancer research. Its application has been shown to activate several transcriptionally silenced genetic elements; however, extent of this activation and other effects on the transcriptome are unknown. Here, we show that zeb...
ORGANISM(S): Arabidopsis thaliana 
2014-11-18 | E-GEOD-63355 | biostudies-arrayexpress
UnknownAn Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir.
Not available
S-EPMC8915250 | biostudies-literature
UnknownContribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme.
Not available
S-EPMC6686228 | biostudies-literature
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