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ProteomicsA potent cytidine deaminase biodegrader sensitises cancer cells to deoxycytidine analogue-based chemotherapies
Deoxycytidine analogues (dC) are chemotherapy agents used to treat a range of solid and blood cancers. However, their clinical efficacy is often limited by resistance mechanisms. Cytidine deaminase (CDA) plays a key role of this resistance by deaminating dC analogues into inactive metabolites. Altho...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD065390 | Pride
Targeted protein degradation Cytarabine Cytidine deaminase Chemotherapy resistance Single domain antibody Lung cancer Biodegrader Pancreatic cancer Gemcitabine 
ProteomicsDevelopment of a p62 biodegrader for autophagy targeted degradation
Harnessing autophagy for targeted degradation of intracellular cargo is a promising extension to proteasome-based targeted protein degradation because of the capacity and versatility of lysosomes, broadening the scope of therapeutic targets. First autophagy-based degraders and glues have been identi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-16 | PXD057810 | Pride
Huh7 p62 ko Huh7 
UnknownDevelopment of a p62 biodegrader for autophagy targeted degradation.
Not available
S-EPMC12675543 | biostudies-literature
UnknownGenome sequence of Rhodococcus sp. strain R04, a polychlorinated-biphenyl biodegrader.
Not available
S-EPMC3165690 | biostudies-literature
UnknownAzoarcus sp. CIB, an anaerobic biodegrader of aromatic compounds shows an endophytic lifestyle.
Not available
S-EPMC4207700 | biostudies-literature
UnknownGenome Sequence of Rhodococcus opacus Strain R7, a Biodegrader of Mono- and Polycyclic Aromatic Hydrocarbons.
Not available
S-EPMC4153479 | biostudies-literature
GenomicsRhodococcus sp. P14
Rhodococcus sp. P14 Genome sequencing and assembly
PRJNA82321 | ENA
UnknownGenome Sequence of "Thalassospira australica" NP3b2T Isolated from St. Kilda Beach, Tasman Sea.
Not available
S-EPMC4241657 | biostudies-literature
UnknownDraft Genome Sequences of Marinobacter similis A3d10T and Marinobacter salarius R9SW1T.
Not available
S-EPMC4031335 | biostudies-literature
ProteomicsIAP-binding intrabodies for concurrent degradation of proto-oncogenes and toggling cell death modalities
Single domain antibodies or antibody mimetics, such as monobodies, can be engineered to degrade undruggable targets via fusion to ubiquitin E3 ligases. In this study we developed multi-targeting biodegrader intrabodies by harnessing an inhibitor of apoptosis (IAP) E3 ligase RING domain, or the IAP-b...
ORGANISM(S): Homo sapiens (Human) 
2026-03-03 | PXD061128 | Pride
Intrabody Cancer Iap protein Drugs Tnf Baf Biodegrader Ciap1 Xiap Bioprotac Smac mimetic Ring Protac Swi/snf Intracellular antibody E3 ligase 
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