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MetabolomicsSerum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy
Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying therapies is essential to reduce inflammation and prevent destruction of the joint. RA is a heterogeneous disease,...
2025-08-14 | MTBLS6213 | MetaboLights
TranscriptomicsExpression data from TNF-stimulated mouse glomeruli
The specific contribution of the two TNF-receptors Tnfr1 and Tnfr2 to TNF-induced inflammation in the glomerulus is unknown. In mice, TNF exposure induces glomerular expression of inflammatory mediators like adhesion molecules and chemokines in vivo, and glomerular accumulation of leukocytes. To exa...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-43928 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human mammary epithelial cells (HMEC) stimulated with TNF vs. controls reveals TNF induces distinct expression programs
HMEC cultures were left untreated or stimulated for 5h with 2 ng/ml TNF. Comparison of the gene expression profiles revealed the TNF-mediated gene expression changes.
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-2638 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human umbilical vein endothelial cells (HUVEC) stimulated with TNF vs. controls reveals TNF induces distinct expression programs
HUVEC were left untreated or stimulated for 5h with 2 ng/ml TNF. Comparsion of the gene profiles revealed TNF-mediated gene expression changes in HUVEC.
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-2639 | biostudies-arrayexpress
TranscriptomicsWhole blood transcriptional profiling of healthy volunteers and rheumatoid arthritis patients treated with methotrexate or anti-TNF therapy after ex vivo whole blood stimulation with TNF
We tested the hypothesis that anti-tumor necrosis factor (TNF) therapy reduces TNF-inducible gene expression in blood. Whole peripheral blood from healthy volunteers and rheumatoid arthritis patients (treated with the monoclonal anti-TNF antibody adalimumab, the soluble TNF receptor etanercept or th...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5094 | biostudies-arrayexpress
TranscriptomicsEffect of human TNF-alpha on adult Schistosoma mansoni gene expression profile
Schistosoma mansoni is the major causative agent of schistosomiasis in the Americas. This parasite takes advantage from host signaling molecules such as cytokines and hormones to complete its development inside the host. TNF-α is the most important cytokine involved in the inflammatory response whe...
ORGANISM(S): Schistosoma mansoni 
2010-06-24 | E-GEOD-16261 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of inducible GATA6L-overexpressing HT-29 cells stimulated with TNF
The objective of this study was to investigate the role of GATA6L with or without TNF stimulation. Microarrays were used to capture the transcriptional response to GATA6L overpexression at intermediate times after TNF stimulation. Cells were induced for GATA6L overexpression and evaluated at two hou...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-72079 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of HT-29 cells stimulated with pairwise combinations of TNF, EGF, and insulin
The objective of this study was to investigate the link between signaling-network activation and transcriptional regulation downstream of tumor necrosis factor (TNF), epidermal growth factor (EGF), and insulin. Microarrays were used to capture the transcriptional responses to TNF, EGF, and insulin a...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-69639 | biostudies-arrayexpress
TranscriptomicsModulation of the TNF-induced macrophage response by synovial fibroblasts
Here we explored how the human macrophage response to tumor necrosis factor (TNF) is regulated by human synovial fibroblasts, the representative stromal cell type in the synovial lining of joints that become activated during inflammatory arthritis. Genome-wide transcriptome analysis (RNAseq) showed ...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-57723 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response
Steady-state gene expression is a coordination of synthesis and decay of RNA through epigenetic regulation, transcription factors, miRNAs, and RNA-binding proteins. Here, we present Bru-Seq and BruChase-Seq to assess genome-wide changes to RNA synthesis and stability in human fibroblasts at homeosta...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-43440 | biostudies-arrayexpress
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