Modulation of the TNF-induced macrophage response by synovial fibroblasts

ABSTRACT: Here we explored how the human macrophage response to tumor necrosis factor (TNF) is regulated by human synovial fibroblasts, the representative stromal cell type in the synovial lining of joints that become activated during inflammatory arthritis. Genome-wide transcriptome analysis (RNAseq) showed that co-cultured synovial fibroblasts modulate the expression of approximately one third of TNF-inducible genes in macrophages, including expression of target genes in pathways important for macrophage survival and polarization towards an alternatively activated phenotype. This work furthers our understanding of the interplay between innate immune and stromal cells during an inflammatory response, one that is particularly relevant to inflammatory arthritis. Our findings also identify modulation

ORGANISM(S): Homo sapiens

SUBMITTER: Laura Donlin 

PROVIDER: E-GEOD-57723 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress