Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse models with liver-specific deletion or global hypomorphic expression of the NADPH-cytochrome P450 reductase gene to study molecular mechanisms for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
NADPH-cytochrome P450 reductase (CPR) is important for the functions of many enzymes, such as microsomal cytochrome P450 (P450) monooxygenases and heme oxygenases. Two mouse models with deficient CPR expression in adults were recently generated in this laboratory: liver-Cpr-null (with liver-specific...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2362 | biostudies-arrayexpress
ProteomicsBiotransformation of efavirenz and proteomic analysis of P450s and UGTs in human, mouse, and macaque brain-derived in vitro systems
Antiretroviral drugs such as efavirenz (EFV) are essential to combat HIV infection in the brain, but little is known about how these drugs are metabolized locally. In this study, the cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT)-dependent metabolism of EFV was probed in brain microsom...
ORGANISM(S): 9606 
2022-10-24 | MSV000090576 | MassIVE
ProteomicsCytochrome P450s protect against oxidative damage via a preferred orientation of the heme cofactor
Cytochrome P450 enzymes (P450s) are a superfamily of monooxygenases that utilise a cysteine thiolate ligated heme moiety to perform a wide range of demanding oxidative transformations. Given the oxidative power of active intermediate formed within P450s during their active cycle, it is remarkable th...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030867 | Pride
Glycopeptide antibiotic (gpa) biosynthesis Cytochrome p450s 
UnknownStructural diversity of eukaryotic membrane cytochrome p450s.
Not available
S-EPMC3682514 | biostudies-literature
UnknownStructural differences between soluble and membrane bound cytochrome P450s.
Not available
S-EPMC4190058 | biostudies-literature
TranscriptomicsTranscription profiling of mouse colon response to quercetin in WT and POR-null animals
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4256 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver response to quercetin in WT and POR-null mice
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4259 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ileum response to quercetin in WT and POR-null mice
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4257 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse POR-null and wild type jejunum response to quercetin
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4258 | biostudies-arrayexpress
UnknownThe Multifarious Link between Cytochrome P450s and Cancer.
Not available
S-EPMC6964729 | biostudies-literature
Sort   by:  
 Page size