Cytokines. retina

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Transcriptomics (337)
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Genomics (41)
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Organisms

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biostudies-arrayexpress (345)
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IRAK-4 Q293X mutation (1)
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Mass Spectrometry (3)
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SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (9)
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DNBelab C Series High-throughput Single-cell RNA Library Preparation Set V3.0 (MGI Tech) (1)
DNBelab C-TaiM droplet generator (MGI Tech) (1)
Avatarget 12-well dual-chamber organ-on-chip system; AvatarFlow Organ Chip Flow Initiation Controller System (Avatarget Co., Ltd., Suzhou, China) (1)
Zephyr G3 NGS workstation (1)
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N/A (1)
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BGISEQ-500 (1)
Illumina HiSeq 3000 (1)
6520A Quadrupole Time-of-Flight LC/MS (1)
Bruker (1)
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Liquid Chromatography MS - alternating - hilic (1)

Publication Date

2010 (63)
2013 (47)
2011 (33)
2015 (32)
2014 (31)
2012 (27)
2008 (24)
2016 (18)
2009 (16)
2007 (11)
2024 (9)
2020 (9)
2022 (8)
2025 (6)
2006 (6)
2026 (5)
2019 (5)
2021 (4)
2023 (3)
2018 (3)
2017 (2)
2005 (2)
2004 (1)

CHEBI ID

CHEBI:18186 (2)
CHEBI:28300 (2)
CHEBI:28044 (2)
CHEBI:78320 (2)
CHEBI:16737 (2)
CHEBI:85552 (1)
CHEBI:182386 (1)
CHEBI:167722 (1)
CHEBI:83454 (1)
CHEBI:135063 (1)
CHEBI:166055 (1)
CHEBI:143735 (1)
CHEBI:167783 (1)
CHEBI:167756 (1)
CHEBI:167819 (1)
CHEBI:64810 (1)
CHEBI:167718 (1)
CHEBI:24684 (1)
CHEBI:149776 (1)
CHEBI:177392 (1)
CHEBI:24673 (1)
CHEBI:181279 (1)
CHEBI:157747 (1)
CHEBI:165782 (1)
CHEBI:193578 (1)
CHEBI:134510 (1)
CHEBI:228529 (1)
CHEBI:89310 (1)
CHEBI:32368 (1)
CHEBI:74168 (1)

Metabolite Name

Xanthurenic_acid (1)
Quinolinic_acid (1)
Picolinic_acid (1)
N-acetylserotonine (1)
Kynurenic_acid (1)
Indoxyl-3-Sulfate (1)
Indole-3-lactic_acid (1)
Indole-3-acetic_acid (1)
Indole_Propionic_acid (1)
5-Hydroxytryptophane (1)
5-Hydroxyindole_acetic_acid (1)
3-OH-kynurenine (1)
3-OH-anthranilic_acid (1)
Indole-3-aldehyde (1)
15-keto Prostaglandin A1, potentially (1)
11-Deoxy prostaglandin F2?, potentially (1)
11-HETE, potentially (1)
12-Hydroxydodecanoic acid, potentially (1)
13(S)-HOTrE, potentially (1)
13,14-Dihydro prostaglandin E1, potentially (1)
13,14-Dihydro-15-keto Prostaglandin J2, potentially (1)
13,14-dihydro-15-keto-tetranor Prostaglandin D2, potentially (1)
15-keto Prostaglandin E1, potentially (1)
2-Hydroxycinnamic acid, potentially (1)
3-[2-(2,3-Dihydroxy-5,6,8a-trimethyloctahydro-2H-spiro[naphthalene-1,2'-oxiran]-5-yl)ethyl]-5-hydroxy-2(5H)-furanone, potentially (1)
5-[5-hydroxy-3-(hydroxymethyl)pentyl]-8a-(hydroxymethyl)-5,6-dimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid, potentially (1)
Azelaic acid, potentially (1)
Bicyclo prostaglandin E2, potentially (1)
Camphanic acid, potentially (1)
Maleic acid, potentially (1)

First Public Date

2014 (3)
2025 (2)
2024 (2)
2026 (1)
2023 (1)
2022 (1)
2021 (1)
2018 (1)
2017 (1)

Study type

Transcription profiling by array (250)
RNA-seq of coding RNA (34)
Unknown experiment type (20)
ChIP-seq (15)
RNA-seq of coding RNA from single cells (5)
Human - High-throughput sequencing (2)
Transcription profiling by RT-PCR (2)
Comparative genomic hybridization by array (2)
Other (2)
Animal - One-color microarray (1)
ChIP-chip by tiling array (1)
Cell line - One-color microarray (1)
Cell line - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
ChIP-chip by array (1)
Single nucleus RNA sequencing (1)
MicroRNA profiling by array (1)
Methylation profiling by array (1)
Proteomic profiling by array (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of total RNA (1)

Release Date

2010 (63)
2013 (53)
2014 (41)
2015 (36)
2011 (35)
2021 (31)
2022 (30)
2012 (30)
2020 (29)
2023 (27)
2008 (25)
2024 (23)
2019 (23)
2016 (22)
2017 (17)
2009 (17)
2025 (15)
2018 (14)
2007 (11)
2006 (6)
2026 (5)
2005 (2)
2004 (1)

Lab affiliation

1Research Unit Protein Science and Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany (1)
Department Functional Proteomics Medizinisches Proteom-Center Ruhr-University Bochum Building ProDi Gesundheitscampus 4 44780 Bochum Germany (1)
Division of Rheumatology, Departments of Medicine and Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (1)

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Ciliary neurotrophic factor induces genes associated with inflammatory response and gliosis in the retina: A gene profiling study of flow-sorted, Muller (glial) cells

Our data suggest that CNTF remodels the transcription profile of Muller (glial) cells leading to induction of networks associated with transcription, cell cycle regulation and inflammatory response. CNTF also appears to function as an inducer of gliosis in the retina. These studies provide new insig...

ORGANISM(S): Mus musculus

2011-08-31 | E-GEOD-27195 | biostudies-arrayexpress

Chemokine expression in retinal pigment epithelial cells in response to co-culture with activated T Cells

Purpose: To investigate the effects of T cell-derived cytokines on gene and protein expression of chemokines in a human RPE cell line (ARPE-19). Methods: We used an in vitro co-culture system in which the RPE and CD3/28-activated T cells were separated by a membrane. Differential gene expression in...

ORGANISM(S): Homo sapiens

2012-11-19 | E-GEOD-36331 | biostudies-arrayexpress

MicroRNA Expression in Human RPE Cells in Culture: Control vs Treated with IFN-? + TNF-? + IL-1?

Human retinal pigment epithelial (HRPE) cells in culture respond to inflammatory cytokines (IFN-? + TNF-? + IL-1? ) by increasing the expression of many cytokines and chemokines. The goal of this study was to delineate the role of miRNA in this process. We employed microarray analysis to study the e...

ORGANISM(S): Homo sapiens

2010-11-11 | E-GEOD-23979 | biostudies-arrayexpress

Leptin and IL-6 family cytokines synergize to stimulate Muller glia reprogramming and retina regeneration.

Not available

S-EPMC4194149 | biostudies-literature

Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration.

Not available

S-EPMC4194164 | biostudies-literature

Antibody-free multiplex measurement of 23 human cytokines in primary cell culture secretome using targeted multiple reaction monitoring mass spectrometry

Cytokines are key mediators of inflammation that commonly serve as biomarkers to monitor immune responses and inflammatory disease. Cytokines are commonly measured by immunoassays, which have limited multiplexing capacity, are costly and can exhibit cross-reactivity. Although multiple reaction monit...

ORGANISM(S): Homo Sapiens

2020-02-19 | PXD015448 | panorama

miR-146a regulates glucose induced upregulation of inflammatory cytokines extracellular matrix proteins in the retina and kidney in diabetes.

Not available

S-EPMC5354466 | biostudies-literature

Cytokines IL-1β and IL-10 are required for Muller glia proliferation following light damage in the adult zebrafish retina.

Not available

S-EPMC11208712 | biostudies-literature

Hyper-Reflecting Foci in Multiple Sclerosis Retina Associate With Macrophage/Microglia-Derived Cytokines in Cerebrospinal Fluid.

Not available

S-EPMC9160385 | biostudies-literature

Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy.