Cytosine deaminase

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Disease

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Mass Spectrometry (4)
Affinity purification coupled with mass spectrometry proteomics (2)
Gel-based experiment (2)
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Instrument Platform

NextSeq 500 (3)
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2019 (13)
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Metabolite Name

Ps(22:2(13Z,16Z)/20:3(6,8,11)-Oh(5)) (1)
Luteolin 3',4'-Di-O-Beta-D-Glucopyranoside (1)
Pi(Txb2/22:4(7Z,10Z,13Z,16Z)) (1)
L-Nil (1)
(R)-1-Methylpiperidine-2-Carboxylic Acid (1)
N-Formimidoyl-Glutamic Acid (1)
N-Methylglutamic Acid (1)
N-[(2-Ethoxypyridin-3-Yl)Methyl]-3-Methylthiophene-2-Carboxamide (1)
Ile Asp Ala (1)
Acetyl-L-Cysteine (1)
2-(3-Hydroxy-1H-Indol-2-Yl)Acetic Acid (1)
Glu Met (1)
3-Oxooctadecanoic Acid (1)
Estriol 16Alpha-(Beta-D-Glucuronide) (1)
Mg(0:0/I-16:0/0:0) (1)
Pyrenochaetic Acid (1)
3-Hexenedioic Acid (1)
5,6-Dihydro-5-Azacytidine (1)
6-Ethyl-5-Hydroxy-3-Oxa-1-Azatricyclo[5.3.1.04,11]Undec-7-En-2-One (1)
Isobutyryl Carnitine (1)
Isobutyryl-L-Carnitine (1)
N-(4-Aminobutyl)-N-Ethylisoluminol (1)
Mabuterol (1)
{[2-(4-Ethoxyphenyl)-1,3-Thiazol-4-Yl]Methyl}[2-(4-Fluorophenyl)Ethyl]Amine (1)
Tosyllysine Chloromethyl Ketone (1)
N-{2-[(2,3-Dimethylphenyl)Amino]Benzoyl}Glutamic Acid (1)
2-((6-Amino-9H-Purin-9-Yl)Methyl)-5-Methyl-3-O-Tolylquinazolin-4(3H)-One (1)
2-Amino-3-(3-Fluoro-4,5-Dihydroxyphenyl)Propanoic Acid (1)
2-(3,4-Dimethoxyphenethyl)-5-Nitro-1H-Benzo[De]Isoquinoline-1,3(2H)-Dione (1)
3-[[(2S)-2,4-Dihydroxy-3,3-Dimethylbutanoyl]Amino]Propanoic Acid (1)

First Public Date

2024 (25)
2019 (16)
2020 (14)
2025 (11)
2023 (11)
2022 (9)
2021 (8)
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2018 (6)
2013 (6)
2015 (3)
2016 (2)
2017 (1)
2014 (1)

Classification

bacteria (2)
fungi (1)
viruses (1)

Study type

Transcription profiling by array (11)
ChIP-seq (8)
RNA-seq of coding RNA (5)
Other (3)
Methylation profiling by high throughput sequencing (3)
RNA-seq of total RNA (3)
Methylation profiling by array (2)
Animal - One-color microarray (1)
Genotyping by array (1)
Bisulfite-seq (1)
Comparative genomic hybridization by array (1)
Hi-C (1)

Release Date

2023 (45)
2025 (39)
2022 (36)
2021 (33)
2019 (30)
2013 (28)
2017 (27)
2016 (26)
2020 (26)
2018 (25)
2024 (23)
2015 (22)
2012 (20)
2014 (15)
2011 (13)
2009 (11)
2026 (7)
2010 (7)
2008 (6)
2007 (6)
2004 (5)
2005 (3)
2006 (2)
2003 (1)
1998 (1)

Lab affiliation

Benjamin A. Garcia, Ph.D., FRSC John McCrea Dickson M.D. Presidential Professor Director of Quantitative Proteomics Penn Epigenetics Institute Department of Biochemistry and Biophysics Smilow Center for Translational Research Perelman School of Medicine University of Pennsylvania Room 9-124 (office) 3400 Civic Center Blvd Philadelphia, PA 19104 215-573-9423 (office) (1)
Cancer Science Institute of Singapore (CSI), National University of Singapore (NUS) (1)
Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands (1)
Proteomics Core Facility and Research Group Proteomics, CEITEC-MU, Masaryk University, Brno, Czech Republic (1)

Tags

pathogen (4)
pathogen:bacterium (2)
pathogen:fungus (1)
pathogen:virus (1)

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Interaction with the CCT chaperonin complex limits cytotoxicity from the APOBEC3A cytosine deaminase.

The APOBEC3 cytosine deaminases are implicated as the cause of a prevalent somatic mutation pattern found in cancer genomes. The APOBEC3 enzymes act as viral restriction factors by mutating viral genomes. Mutation of the cellular genome is presumed to be an off-target activity of the enzymes, althou...

ORGANISM(S): Homo sapiens (Human)

2021-07-02 | PXD024191 | Pride

Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-FU-Mediated Cytotoxicity in Multiple Human Cancer Types

Toca 511 is a modified Retroviral Replicating Vector based on Moloney gâ€‘retrovirus with an amphotropic envelope. As an investigational cancer treatment, Toca 511 preferentially infects cancer cells without direct cell lysis and encodes an enhanced yeast cytosine deaminase that converts the antifun...

ORGANISM(S): Homo sapiens

2015-11-01 | E-GEOD-72955 | biostudies-arrayexpress

Improved cytotoxic effects of Salmonella-producing cytosine deaminase in tumour cells.

Not available

S-EPMC4321383 | biostudies-literature

Computational Design of a Photocontrolled Cytosine Deaminase.

Not available

S-EPMC6830878 | biostudies-literature

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

PRJNA625079 | ENA

High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase.

Not available