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MetabolomicsComparative Analyses of Metabolomic Fingerprints and Cytotoxic Activities of Soft Corals from the Colombian Caribbean
Soft corals (Cnidaria, Anthozoa, Octocorallia) are a diverse group of marine invertebrates that inhabit various marine environments in tropical and subtropical areas. Several species are recognized as prolific sources of compounds with a wide array of biological activities. Recent advances in analyt...
2018-11-08 | MTBLS777 | MetaboLights
MetabolomicsMetabolite of esculetin plays an important role in cytotoxic effects induced by chloroquine on porcine immature Sertoli cells

Chloroquine (CQ) is widely used in the therapy against malarial, tumor and recently the COVID-19 pandemic, as a lysosomotropic agent to inhibit the endolysosomal trafficking in the autophagy pathway. We previously reported that CQ (20 µM, 36 h) could reprogram transcriptome and impair multiple si...

2024-07-08 | MTBLS9273 | MetaboLights
MetabolomicsNanoinducers-mediated Mitochondria-Selective Degradation Enhance T Cell Immunotherapy Against Multiple Cancers

Cancer immunotherapy utilizing cytotoxic T lymphocytes (CTLs) has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondria content and their resis...

2025-03-13 | MTBLS12284 | MetaboLights
TranscriptomicsGene expression profiles of Hodgkin’s lymphoma cell lines with different sensitivity to cytotoxic drugs
By using high-density DNA microarrays, we analyzed the gene-expression profile of Hodgkin's lymphoma cell lines. Furthermore, we tested the sensitivity of these cell lines for cytotoxic drugs (cisplatin, etoposide, melphalan) and compared the gene-expression profile of chemotherapy-resistant and -se...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-26325 | biostudies-arrayexpress
MetabolomicsComparative metabolomic profiling and biological activities of Zygostelma benthamii Baill. (apocynaceae): unveiling organ-specific antioxidant, anti-inflammatory, and cytotoxic potentials

Zygostelma benthamii has been prized for its medicinal properties and is similar to ginseng. However, the specific chemicals in its various parts and their relationship to its therapeutic effects have not been thoroughly researched. Thus, we used a comprehensive metabolomics approach, LC-MS/MS an...

2026-07-29 | MTBLS15042 | MetaboLights
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
MetabolomicsTraditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma
Carica papaya leaf decoction, an Australian Aboriginal remedy, has been used widely for its healing capabilities against cancer, with numerous anecdotal reports. In this study we investigated its in vitro cytotoxicity on human squamous cell carcinoma cells followed by metabolomic profiling of Carica...
2017-05-04 | MTBLS274 | MetaboLights
TranscriptomicsA microRNA-directed program of cytotoxic CD8+ T cell differentiation
Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs). Here we show that inflammatory signals regulate Dicer expression in CTL, and that deletion or depletion of Dicer in mouse or human activated CD8+ T cells causes upregulation of perforin, granzyme an...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-51393 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptomic analysis of NK cell dynamics in myeloma patients reveal persistent reduction of cytotoxic NK cells from diagnosis to relapse
Single-cell transcriptomics was performed to investigate the bone marrow NK cell compartment of myeloma patients at diagnosis (n=19), during treatment (n=21) and at relapse (n=6). The bone marrow of myeloma patients is characterized by a reduction in conventional cytotoxic NK cells that persists thr...
2023-07-18 | E-MTAB-13157 | biostudies-arrayexpress
ProteomicsM.musculus - T cell, SC (Hukelmannetal,natimmunol2016)
abundance based on Spectral counting, Interaction consistency score: 16.2, Coverage: 30
ORGANISM(S): 10090 
2016-00-00 | 190918057 | PAXDB
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