Cytotoxic t lymphocytes

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Unknown (2759)
Transcriptomics (619)
Genomics (518)
Proteomics (67)
Models (24)
Other (15)
Clinical (8)
Metabolomics (8)
Genomic (4)
Methylation profiling (4)

Organisms

Homo sapiens (417)
Mus musculus (340)
Andropogon gerardi (38)
Bacteria (38)
Canis lupus familiaris (38)
Cnidaria (38)
Cricetulus griseus (38)
Eukaryota (38)
Fasciola (38)
Hepatitis B virus (38)
Bos taurus (5)
Macaca mulatta (5)
Mus sp. (2)
Rattus norvegicus (2)
Sus scrofa (2)
Gallus gallus (2)
Influenza A virus (A/X-31(H3N2)) (1)
Murinae (1)
gut metagenome (1)
Staphylococcus aureus subsp. aureus RN4220 (1)
Thermoplasma acidophilum DSM 1728 (1)
Ictalurus punctatus (1)
Marmota monax (1)
Chlorocebus sabaeus (1)
Mycobacterium tuberculosis (1)
Salmo salar (1)
Ovis aries (1)
Salmo trutta (1)
Felis catus (1)
Oncorhynchus mykiss (1)

Organisms

Homo sapiens (180)
Mus musculus (160)
Gallus gallus (2)
Salmo trutta (1)
Mus musculus musculus (1)
Macaca mulatta (1)
Felis catus (1)
Sus scrofa (1)
Capra hircus (1)

Repository

ENA (396)
biostudies-arrayexpress (348)
geo (340)
EGA (75)
pride (38)
BioModels (19)
MassIVE (16)
MetaboLights (8)
Cell Collective (5)
dbGaP (4)
iProX (4)
GPMDB (3)
jPOST (3)
PAXDB (1)

Tissue

T cell (19)
Cell culture (12)
Spleen (7)
CD8-positive (6)
Cytotoxic T-lymphocyte (4)
Lymph node (3)
Cell suspension culture (2)
Cytotoxic T cell (2)
Macrophage (2)
Primary cell (2)
B cell (1)
C1R cell (1)
Epithelial cell (1)
Leukocyte (1)
Lung (1)
Lymphocyte (1)
Malignant cell (1)
Mucosal melanoma cell (1)
Peripheral blood (1)
Permanent cell line cell (1)
Prostate cancer cell (1)
SUP-T1 cell (1)
Seminal vesicle (1)
Skin (1)
Small intestine (1)
Urinary bladder (1)

Disease

Colorectal Neoplasms (4)
Not Available (3)
Influenza (2)
Normal (2)
Lymphoma (2)
Active ITP (1)
Cytomegalovirus seropositive (1)
Represent tolerant CD4+ T cells that have not been activated (1)
Lung large cell carcinoma (1)
Gastric and colorectal cancer with clinical stage II/III (1)
Carcinoma, Squamous Cell (1)
Colonic Neoplasms (1)
Colorectal Cancer (1)
Celiac disease (1)
Chronic myeloid leukemia (1)
Signet ring cell adenocarcinoma (1)
T-cell large granular lymphocyte leukemia (1)

Technology Type

Mass Spectrometry (38)
Shotgun proteomics (23)
Bottom-up proteomics (8)
Mass spectrometry (5)
Mass spectrometry assay (3)
Data-dependent acquisition (3)
Data-independent acquisition (3)
Top-down proteomics (2)
Illumina Oncoscan Array (1)
ILLUMINA, Illumina HiSeq 2500, NextSeq 500, Nanostring (1)
NextSeq 500, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2500 (1)
All-ion fragmentation (1)
DiaPASEF (1)
Gel-based experiment (1)
HDMSE (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (17)
Illumina HiSeq 2500 (9)
Illumina HiSeq 4000 (8)
NextSeq 500 (4)
Illumina NovaSeq X (3)
DNBSEQ-T7 (2)
NextSeq 550 (2)
NanoString nCounter (1)
10X Genomics Single Cell, V3.1 (1)
RStudio and R with illuminaio, sva and BioMart packages (1)
HumanHT-12 V4 beadarray (1)
Illumina TotalPre-96 RNA Amp kit (1)
NucleoSpin RNA kit, NanoDrop ND-1000 and Agilent 2100 bioanalyzer (1)
Dynabeads CD8+ isolation kit (1)
Local workstation (1)
Chromium Single Cell 5' Library & Gel Bead Kit v2 (1)
FLOQSwab (Copan) (1)
MoFlo XDP (Beckman Coulter) or a FACSAria II (Becton Dickinson) (1)
Fluidigm C1 autoprep system (1)
BD FACSAria III (1)
Centrifuge (1)
Agilent Technologies Scanner G2505C (1)
ScanArray [PerkinElmer] (1)
NextSeq 1000 (1)
TruSeq (Illumina, Novogene, Genomic Centre Cambridge, CB4 0FW, UK.) (1)
NanoDrop spectrophotometer and the Agilent 2100 Bioanalyzer (1)
Histopaque-1077,FACSAria Fusion Sorter,Flow Cytometer (1)
10x Genomics Chromium Controller (1)
NextSeq 2000 (1)
BGISEQ-500 (1)

Publication Date

2024 (77)
2025 (69)
2023 (64)
2026 (53)
2013 (53)
2015 (51)
2021 (49)
2022 (38)
2012 (38)
2016 (36)
2010 (35)
2014 (34)
2020 (29)
2008 (28)
2011 (25)
2018 (24)
2009 (20)
2017 (17)
2019 (15)
2007 (8)
2005 (4)
2006 (4)
2004 (2)
2027 (1)

UNIPROT ID/AC

Q14609 (1)
1433B_MOUSE (1)
1433E_MOUSE (1)
1433F_MOUSE (1)
1433G_MOUSE (1)
1433S_MOUSE (1)
1433T_MOUSE (1)
1433Z_MOUSE (1)
2A5A_MOUSE (1)
2A5E_MOUSE (1)
2A5G_MOUSE (1)
2AAA_MOUSE (1)
2AAB_MOUSE (1)
2ABA_MOUSE (1)
2ABD_MOUSE (1)
3BP1_MOUSE (1)
3BP2_MOUSE (1)
3BP5L_MOUSE (1)
3HAO_MOUSE (1)
3HIDH_MOUSE (1)
3MG_MOUSE (1)
41_MOUSE (1)
4EBP1_MOUSE (1)
4EBP2_MOUSE (1)
4ET_MOUSE (1)
4F2_MOUSE (1)
5NT3A_MOUSE (1)
5NT3B_MOUSE (1)
5NTC_MOUSE (1)
6PGD_MOUSE (1)

CHEBI ID

CHEBI:59132 (1)
CHEBI:71559 (1)
CHEBI:57614 (1)
CHEBI:91144 (1)
CHEBI:89582 (1)
CHEBI:40521 (1)
CHEBI:17482 (1)
CHEBI:74067 (1)
CHEBI:84838 (1)
CHEBI:73039 (1)
CHEBI:21563 (1)
CHEBI:73074 (1)
CHEBI:17822 (1)
CHEBI:18186 (1)
CHEBI:15676 (1)
CHEBI:73026 (1)
CHEBI:15956 (1)
CHEBI:64489 (1)
CHEBI:16668 (1)
CHEBI:16977 (1)
CHEBI:15428 (1)
CHEBI:17268 (1)
CHEBI:28044 (1)
CHEBI:19289 (1)
CHEBI:27747 (1)
CHEBI:17196 (1)
CHEBI:18347 (1)
CHEBI:73024 (1)
CHEBI:73579 (1)
CHEBI:17203 (1)

Metabolite Name

Hydroxyurea (3)
Uracil (3)
Thymine (3)
L-Proline (3)
L-Tryptophan (3)
Creatine (3)
L-Tyrosine (3)
3-Aminopropionitrile (2)
Glycerophosphoric acid (2)
1,2-Dipentadecanoyl-sn-glycero-3-phosphocholine (2)
Phe-Glu (2)
3'-Adenylic acid (2)
Ginsenoside F1 (2)
Dicyclohexylamine (2)
Mibefradil (2)
D-Ornithine (2)
S-Lactoylglutathione (2)
Cysteine (2)
Salicylaldehyde (2)
N,N-Dimethylarginine (2)
2'-Deoxyadenosine (2)
L-Allothreonine (2)
Linoleamide (2)
L-Cystine (2)
1-Methylguanosine (2)
Creatinine (2)
L-Alanine (2)
Betaine (2)
Arabinosylhypoxanthine (2)
N1-Acetylspermidine (2)

First Public Date

2023 (62)
2025 (57)
2024 (51)
2026 (45)
2021 (40)
2022 (31)
2014 (27)
2020 (24)
2018 (19)
2017 (17)
2019 (12)
2015 (6)
2016 (4)
2013 (1)

Modelling Approach

Ordinary differential equation model (16)

Study status

Completed (6)
Active, not recruiting (1)
Recruiting (1)

Lab affiliation

Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, CB2 0XY, UK (3)
Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK (3)
Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421 Homburg, Germany (2)
Systems Inflammation group, Centre of Molecular Inflammation Research (CEMIR), and Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Norway (2)
Université de Lille, Sciences et Technologies - INSERM U1192 - Laboratoire PRISM, France (2)
225, Veterinary Medical Center University of Minnesota 1365, Gortner Avenue St. Paul, MN 55108 (1)
Cambridge Institute for Medical Research, University of Cambridge, UK (1)
Cell Signalling & Immunology, School of Life Sciences, University of Dundee (1)
Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK (1)
Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK. (1)
Department of Biochemistry, Escola Paulista de Medicina, Federal University of São Paulo, (EPM/UNIFESP), São Paulo, SP, Brazil. (1)
Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA. (1)
Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15784, Athens, Greece (1)
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany. NNF Center for Protein Research, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark. (1)
Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, UK (1)
Helmholtz Centre for Infection Research (1)
Institut für Experimentelle Medizin (IEM) Arbeitsgruppe Systematische Proteomforschung Christian-Albrechts-Universität zu Kiel Niemannsweg 11 24105 Kiel, Germany (1)
Interdisciplinary research center HALOmem, Institute of Biochemistry and Biotechnology, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Halle, Germany (1)
Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, China (1)
Leibniz Institute for Experimental Virology (HPI), Germany; Centre for Structural Systems Biology, Germany; 5European XFEL GmbH, Germany. (1)
MRC Protein Phosphorylation and Ubiquitylation Unit (PPU), School of Life Sciences, University of Dundee, Dundee, United Kingdom. (1)
Molecular Cell Biolody, Weizmann Institute of Science. (1)
Prof. Dr. Henning Urlaub Max-Planck-Institute for Biophysical Chemistry Bioanalytical Mass Spectrometry Group Am Fassberg 11 D-37077 Goettingen, Germany University Medical Center Goettingen Bioanalytics Institute for Clinical Chemistry Robert Koch Strasse 40 D-37075 Goettingen, Germany (1)
Proteomics Unit - Dpt. of Macromolecular Structures - Spanish National Biotechnolgy Centre (CNB-CSIC) (1)
Proteomics, Beatson Institute for Cancer Research, Glasgow,UK (1)
School of Life Sciences, University of Dundee, Dundee (1)
School of Life Sciences, University of Dundee, Dundee, UK(lab head) (1)
TDI Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK (1)
Unit of Chemical Proteomics, Division of Chemistry I, Dept. of Medical Biochemistry and Biophysics (MBB), Karolnska Institutet, Biomedicum, Solna, Sweden (1)
University of California San Diego (1)

Keyword

Tremelimumab (2)
Durvalumab (2)
Oncolytic Vaccinia Virus (1)
Tumor Cell Death (1)
Viral Therapy (1)
Anti-Tumor Immunity (1)
Metastatic Melanoma (1)
Neoantigen (1)
Human Epidermal Growth Factor Receptor 2 (1)
Salivary Gland (1)
Breast (1)
Fludarabine (1)
Fludarabine phosphate (1)
Cyclophosphamide (1)
Lung (1)
Esophageal (1)
FOLFOX (1)
Pancreatic (1)
Colorectal (1)
Gastric (1)
Bladder (1)
Metastatic colorectal cancer (1)
HER2 (1)

IsPrivate

False (19)

Submitter Keywords

Immuno-oncology (10)

Modification

144.102062 (1)
15.994915 (1)
45.987721 (1)

Study type

Transcription profiling by array (231)
RNA-seq of coding RNA (43)
RNA-seq of coding RNA from single cells (20)
ChIP-seq (15)
Methylation profiling by array (8)
Interventional (6)
Proteomic profiling by array (5)
DNA-seq (3)
Unknown experiment type (2)
Human - One-color microarray (2)
Transcription profiling by RT-PCR (2)
Comparative genomic hybridization by array (2)
MicroRNA profiling by array (2)
RNA-seq of total RNA (2)
RNA-seq of non coding RNA (2)
Observational (2)
RNA-seq of non coding RNA from single cells (1)
Cell line - Two-color microarray (1)
Animal - One-color microarray (1)
ChIP-chip by tiling array (1)
Human - Single-cell sequencing (1)
Transcription profiling by tiling array (1)
ATAC-seq (1)
Other (1)

Release Date

2022 (359)
2023 (278)
2021 (274)
2020 (251)
2025 (240)
2024 (218)
2019 (171)
2018 (170)
2017 (144)
2015 (142)
2016 (136)
2014 (121)
2013 (98)
2012 (83)
2010 (74)
2011 (67)
2009 (51)
2008 (46)
2007 (40)
2026 (32)
2006 (32)
2005 (15)
2003 (14)
2004 (12)
2001 (12)
2000 (8)
1998 (7)
1999 (6)
2002 (4)
1997 (1)

Location

France (4)
United States (2)
China (1)
Japan (1)

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Nanoinducers-mediated Mitochondria-Selective Degradation Enhance T Cell Immunotherapy Against Multiple Cancers

Cancer immunotherapy utilizing cytotoxic T lymphocytes (CTLs) has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondria content and their resis...

2025-03-13 | MTBLS12284 | MetaboLights

Comparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells

Introduction

Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to a hyperactive and prolonged inflammation triggered by proinflammatory immune cells, transitioning to the repair and healing phase is halted. T cells may exacerbate the proinflammatory mil...

2025-07-09 | MTBLS9800 | MetaboLights

M.musculus - T cell, SC (Hukelmannetal,natimmunol2016)

abundance based on Spectral counting, Interaction consistency score: 16.2, Coverage: 30

ORGANISM(S): 10090

2016-00-00 | 190918057 | PAXDB

Transcription profiling of human T-lymphocytes from the adaptive immune system from smojers and non smokers

Cigarette smoke components have a proven negative influence on human health. Adverse metabolic effects have been observed in tissues and single cells. As T-lymphocytes get in contact with affected organs (e.g. lung) or cells (e.g.erythrocytes), as well as with smoke components and bioactive molecule...

ORGANISM(S): Homo sapiens

2008-06-13 | E-GEOD-4806 | biostudies-arrayexpress

RNA-seq of Cdc42 knockout murine cytotoxic T lymphocytes

This project explores the effects of Cdc42 gene-knock in effector cytotoxic T lymphocytes (CTLs). Effector CTLs were differentiated from OTI TCR transgenic mice for 5 days in vitro, then nucleofected with CRISPR/Cas9 RNPs targeting Cdc42 or non-targeting sequence.

ORGANISM(S): Mus musculus

2025-07-29 | E-MTAB-14519 | biostudies-arrayexpress

A microRNA-directed program of cytotoxic CD8+ T cell differentiation

Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs). Here we show that inflammatory signals regulate Dicer expression in CTL, and that deletion or depletion of Dicer in mouse or human activated CD8+ T cells causes upregulation of perforin, granzyme an...

ORGANISM(S): Mus musculus

2013-12-02 | E-GEOD-51393 | biostudies-arrayexpress

Fuzheng Jiedu Xiaoji Formula Enhances Anti-PD-1 Therapy for Hepatocellular Carcinoma by Inhibiting Regulatory T Cell Lipotoxicity

Background: The objective response rate of anti-programmed death receptor 1 (PD-1) immunotherapy in hepatocellular carcinoma (HCC) remains limited. The tumor immunosuppressive microenvironment mediated by regulatory T cells (Tregs) is a key bottleneck. The traditional Chinese medicine (TCM) compo...

2025-12-05 | MTBLS13458 | MetaboLights

The impact of hypoxia on the cytotoxic T lymphocyte proteome

Metabolic and nutrient-sensing pathways play an important role in controlling the efficacy of effector T cells. Oxygen is a critical regulator of cellular metabolism. However, during immune responses T cells must function in oxygen-deficient, or hypoxic, environments. Here, we used high resolution m...

ORGANISM(S): Mus musculus (Mouse)

2021-10-20 | PXD026223 | Pride

Transcription profiling of human CMV-stimulated CD69+, hCMV-stimulated CD69- and unstimulated monoclonal CD4+ T-LGL lymphocytes from peripheral blood samples from four TCRVbeta+/CD4+ T-LGL lymphocytosis patients

Recent studies suggest the potential involvement of common antigenic stimuli on the ontogeny of monoclonal TCRalphabeta+/CD4+/NKa+/CD8-/+dim T-large granular lymphocyte (LGL) lymphocytosis. Since healthy individuals show (oligo)clonal expansions of hCMV-specific TCRVbeta+/CD4+/cytotoxic/memory T-cel...

ORGANISM(S): Homo sapiens

2008-10-25 | E-GEOD-12488 | biostudies-arrayexpress

Transcription profiling of human T cell lines isolated from tumor infiltrating lymphocytes or peripheral blood lymphocytes of a patient with large cell carcinoma of the lung

The IGR-Heu tumor cell line was established from patient Heu suffering from large cell carcinoma of the lung. Heu171, Heu127 and Heu161 T cell clones were isolated from autologous tumor infiltrating lymphocytes. H32 T cell line and H32-22 clone were isolated from autologous PBL after stimulation wit...

ORGANISM(S): Homo sapiens

2007-03-02 | E-TABM-208 | biostudies-arrayexpress

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