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Human cytotrophoblast organoids
The mechanisms by which the placenta adapts to exogenous stimuli to create a stable and healthy environment for the growing fetus are not well known. Low oxygen tension and sub-optimal vitamin D levels influence placental function and both are associated with preeclampsia, a condition associated wit...
ORGANISM(S): Homo sapiens 
Human cytotrophoblast organoid cultures were established from the villous trophoblast of first trimester placentas. We analyzed the global expression profile of the cytotrophoblast organoids (CTB-ORG) and compared to the profile of the tissue of origin i.e. villous cytotrophoblast (vCTB) as well as ...
ORGANISM(S): Homo sapiens 
2018-08-02 | GSE109976 | GEO
Abnormal trophoblast invasion is associated with the most common and most severe complications of human pregnancy. The biology of invasion, as well as the etiology of abnormal invasion remains poorly understood. The aim of this study was to characterize the transcriptome of the HTR-8/SVneo human c...
ORGANISM(S): Homo sapiens 
During human pregnancy, placental cytotrophoblasts invade the uterus and its blood vessels, anchoring the progeny and rerouting maternal blood to the embryo/fetus. In preeclampsia, cytotrophoblast invasion is restricted and blood flow to the placenta is reduced. The causes of restricted cytotrophobl...
ORGANISM(S): Homo sapiens 
The mechanisms by which the placenta adapts to exogenous stimuli to create a stable and healthy environment for the growing fetus are not well known. Low oxygen tension and sub-optimal vitamin D levels influence placental function and both are associated with preeclampsia, a condition associated wit...
ORGANISM(S): Homo sapiens 
Primary term human cytotrophoblast, untreated [ChIP-Seq]
Impact of shear stress of cytotrophoblast stem cell derived from naïve PSC
Placental cytotrophoblast microvillar stabilization is required for cell-cell fusion
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