Sort   by:  
 Page size 
TranscriptomicsEffects of DAC treatment
Reversal of gene promoter DNA hypermethylation and associated abnormal gene silencing is an attractive approach to cancer therapy. The DNA methylation inhibitor, decitabine (5-aza-2'-deoxycitidine), is proving efficacious for hematological neoplasms especially at lower, less toxic, doses. Experiment...
ORGANISM(S): Homo sapiens 
2012-03-21 | E-GEOD-20945 | biostudies-arrayexpress
ProteomicsDifferential antibody capture pneumonia samples Chicago cohort
We performed a DAC assay for both cohorts to obtain autoantibody binding profiles. The assay is based on the immunoprecipitation of immunoglobulins from the serum/plasma of the patients and subsequent incubation with a pool of tissue proteins. In the case of the COVID-19 experiment, we selected the ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-14 | PXD051982 | Pride
Covid-19 Dac 
ProteomicsDifferential antibody capture pneumonia samples Munich cohort
We performed a DAC assay for both cohorts to obtain autoantibody binding profiles. The assay is based on the immunoprecipitation of immunoglobulins from the serum/plasma of the patients and subsequent incubation with a pool of tissue proteins. In the case of the COVID-19 experiment, we selected the ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-14 | PXD051948 | Pride
Dac Covid-19 
TranscriptomicsGenes activated by 5-aza-dC (DAC) in pancreatic (KPC-Brca1) cancer-associated fibroblasts (CAFs)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer we used the DNA demethylating drug 5-aza-2’-deoxycytidine (DAC) in a KrasLSL-G12D; p53LSL-R270H/+; Pdx1-cre; Brca1flex2/flex2 (KPC-Brca1) mouse model of agg...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-42364 | biostudies-arrayexpress
TranscriptomicsGenes activated by 5-aza-dC (DAC) in pancreatic cancer (KPC-Brca1) epithelial cells
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer we used the DNA demethylating drug 5-aza-2’-deoxycytidine (DAC) in a KrasLSL-G12D; p53LSL-R270H/+; Pdx1-cre; Brca1flex2/flex2 (KPC-Brca1) mouse model of agg...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-42365 | biostudies-arrayexpress
GenomicsMicroRNAs regulated by DAC
MicroRNAs regulated by DAC
PRJNA115427 | ENA
TranscriptomicsLong term DNMT inhibition in SKM1 cells
SKM-1 cells were cultured for 28 days in the absence or presence of low doses of the DNMT1 inhibitors DAC (10 nM) or AZA (100 nM). The experiment was carried in two independent set at different times, and with 2 replicates for each condition (Ctl, AZA, DAC) for a total of 12 samples. The SKM-1 cell ...
ORGANISM(S): Homo sapiens 
2013-12-11 | E-MTAB-2130 | biostudies-arrayexpress
TranscriptomicsGene expression changes following demethylation by 5-aza-2'-deoxycytidine（decitabine, DAC）in mouse T cell lymphoma EL4 cells
Our study had shown that DAC treatment enhanced immunogenecity of EL4 cells. To explore the mechanisms of DAC-induced tumor immunity, we carried out cDNA microarray analyses to compare the differential expression of genes between DAC and PBS treated EL4 cells. Two-condition experiment, PBS treated E...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-38473 | biostudies-arrayexpress
TranscriptomicsGenes regulated by miR-34b/c and DAC
We found frequent epigenetic silencing of microRNA-34b/c in human colorectal cancer. Introduction of miR-34b/c into a colorectal cancer cell line induced significant changes in gene expression profile. We also found overlap between the genes downregulated by miR-34b/c and those downregulated by DAC....
ORGANISM(S): Homo sapiens 
2008-04-30 | E-GEOD-10455 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression data from human breast cancer cell lines after demethylation treatment.
The contribution of aberrant DNA methylation and the downstream effects in tumorogenesis through silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations can be reversed, we investigated the effects of the epigenetic therapy in breast cancer ...
ORGANISM(S): Homo sapiens 
2012-01-24 | E-GEOD-28969 | biostudies-arrayexpress
Sort   by:  
 Page size