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TranscriptomicsTranscription profiling of C. elegans mutants daf-2(e1368) and daf-2(e1368);pmk-1(km25), between daf-2(e1368), daf-2(e1368);daf-16(mgDf47)
Analysis of genes differentially expressed between daf-2(e1368) and daf-2(e1368);pmk-1(km25) and between daf-2(e1368) and daf-2(e1368);daf-16(mgDf47). These studies identified genes upregulated by wild-type PMK-1 and wild-type DAF-16. Experiment Overall Design: Three independent biological replicat...
ORGANISM(S): Caenorhabditis elegans 
2008-06-14 | E-GEOD-5801 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans long luved daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) reveals insights into longevity
Analysis of gene expression in long-lived daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) allele. DAF-2 regulates DAF-16, a transcription factor. Results provide insight into longevity.
ORGANISM(S): Caenorhabditis elegans 
2007-07-05 | E-GEOD-1762 | biostudies-arrayexpress
TranscriptomicsC. elegans microarrays: daf-2(-) vs. daf-2(-) xbp-1(-)
Transcriptional profiling of day 1 animals comparing untreated daf-2(-) animals and daf-2(-) xbp-1(-) animals. Goal was to identify genes whose expression in daf-2 mutants is dependent (directly or indirectly) on xbp-1. Two-condition experiment, daf-2(-) animals and daf-2(-) xbp-1(-) animals. 4 Biol...
ORGANISM(S): Caenorhabditis elegans 
2010-02-02 | E-GEOD-20148 | biostudies-arrayexpress
TranscriptomicsAdult C. elegans: Control daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi
Transcriptional profiling of adult C. elegans comparing daf-16(-); daf-2(-) animals with adult daf-2(-) animals. Two-condition experiment, daf-2 mutants treated with daf-16 RNAi vs. daf-2 mutants treated with empty vector RNAi. Biological replicates: 8 daf-2 mutants treated with daf-16 RNAi vs. daf-...
ORGANISM(S): Caenorhabditis elegans 
2010-05-16 | E-GEOD-18561 | biostudies-arrayexpress
TranscriptomicsDivergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/Insulin/IGF-receptor pathway
To identify genes that selectively regulate hypoxic sensitivity, we compared the whole-organismal transcriptomes of three daf-2 reduction-of-function alleles, all of which are hypoxia resistant, thermotolerant, and long lived but differ in their rank of severities for these phenotypes. The transcrip...
ORGANISM(S): Caenorhabditis elegans 
2010-06-20 | E-GEOD-18601 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of long-lived C.elegans daf-2 pathway mutants with wild type/short-lived mutants
Comparison of long-lived daf-2 pathway mutants with wild type/short-lived mutants. A: age-1 fer-15; fem-1 vs. fer-15; fem-1. B: age-1 fer-15; fem-1 vs. fer-15; fem-1. C: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. D: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. E: daf-16::gfp in daf...
ORGANISM(S): Caenorhabditis elegans 
2003-07-17 | E-MEXP-7 | biostudies-arrayexpress
Proteomicswt vs daf-2 C. elegans protein turnover
Most aging hypotheses revolve around the accumulation of some sort of damage resulting in gradual physiological decline and ultimately death. Avoiding protein damage accumulation by enhanced turnover should slow down the aging process and extend lifespan. However, lowering translational efficiency e...
ORGANISM(S): Caenorhabditis elegans 
2016-09-27 | PXD002317 | Pride
C. elegans Turnover N15 
TranscriptomicsC. elegans microarrays: daf-2(-) vs. daf-2(-) xbp-1(-)
Transcriptional profiling of day 1 animals comparing untreated daf-2(-) animals and daf-2(-) xbp-1(-) animals. Goal was to identify genes whose expression in daf-2 mutants is dependent (directly or indirectly) on xbp-1.
ORGANISM(S): Caenorhabditis elegans 
2010-02-03 | GSE20148 | GEO
TranscriptomicsRNAseq of dauer-forming C. elegans L2d in daf-2 and daf-2;daf-42
Under adverse environmental conditions, nematodes arrest into dauer, an alternative developmental stage for diapause. Dauers endure unfavorable environment and interact with host animals to access favorable environments, thus playing a critical role in the survival of both free-living and parasitic ...
ORGANISM(S): Caenorhabditis elegans 
2023-04-23 | GSE230353 | GEO
TranscriptomicsExpression analysis of C. elegans wild-type N2 and rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutants
Investigation of whole genome gene expression level changes in C. elegans rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutant compared to the wild-type N2 strain. The mutants have altered longevity phenotypes. The mutants analyzed in this study are further described in Di Chen, Patrick Wai-L...
ORGANISM(S): Caenorhabditis elegans 
2013-11-14 | GSE52340 | GEO
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