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TranscriptomicsThe epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women
Background Obesity is associated with changes in fat cell gene expression and metabolism. What drives these changes is not well understood. We aimed to explore fat cell epigenetics, i.e., DNA methylation, as one mediator of gene regulation, in obese women. The global DNA methylome for abdominal subc...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-67024 | biostudies-arrayexpress
TranscriptomicsGene Expression in Peripheral Blood Leucocytes in Monozygotic Twins Discordant for Chronic Fatigue
Background. Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes. Methods. Cases were 44 individuals who were clinically ev...
ORGANISM(S): Homo sapiens 
2009-05-12 | E-GEOD-16059 | biostudies-arrayexpress
TranscriptomicsInterplay between AP-1 and ERalpha in regulating gene expression and proliferation networks in breast cancer cells
Estrogen receptor alpha (ERalpha) is a ligand-dependent transcription factor that plays an important role in breast cancer. Estrogen-dependent gene regulation by ERalpha can be mediated by interaction with other DNA-binding proteins, such as activator protein-1 (AP-1). The nature of such interaction...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36586 | biostudies-arrayexpress
TranscriptomicsThe fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
Background/Objectives: Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many sm...
ORGANISM(S): Homo sapiens 
2015-05-06 | E-GEOD-58622 | biostudies-arrayexpress
TranscriptomicsC-peptide regulates early transcription in rat proximal tubular cells
C-peptide exerts beneficial effects on glomerular hyperfiltration in type I diabetic patients. As C-peptide localizes to the nucleus, we investigated the transcriptional activities of C-peptide in proximal tubular cells isolated from diabetic rats. Two groups of proximal tubular cells isolated from ...
ORGANISM(S): Rattus norvegicus 
2011-07-26 | E-GEOD-24687 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse soleus muscle to detect differently expressed genes between male BERKO and WT mice
Male skeletal muscles are generally faster and have a higher maximum power output than female muscles. Conversely, during repeated contractions female muscles sre generally more fatigue resistant and recover faster. we hypothesized that estrogen receptor beta is involved in this gender difference. T...
ORGANISM(S): Mus musculus 
2007-10-05 | E-GEOD-1050 | biostudies-arrayexpress
TranscriptomicsInsights into the proliferation and invasiveness of breast cancer from genome-wide profiling of estrogen receptor beta 2
The human ERβ variant, ERβ2, is expressed at higher levels than ERβ1 in many breast cancer cell lines and breast tumours and increasing evidence supports the hypothesis that ERβ2, in contrast to ERβ1, is associated with aggressive phenotypes of various cancers. We identified a breast cancer cell lin...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-57379 | biostudies-arrayexpress
TranscriptomicsMastermind-like protein 1 regulates DNA methylation and expression of early developmental gene clusters in human embryonic kidney cells (expression)
Mastermind-like 1 (MAML1) is a transcriptional coregulator that has been associated with early development of many systems such as neuronal, muscular, cardiovascular and urogenital. The present study aimed to explore the genome-wide effects of MAML1 on gene expression and DNA methylation in human em...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-62175 | biostudies-arrayexpress
TranscriptomicsMastermind-like protein 1 regulates DNA methylation and expression of early developmental gene clusters in human embryonic kidney cells (methylation)
Mastermind-like 1 (MAML1) is a transcriptional coregulator that has been associated with early development of many systems such as neuronal, muscular, cardiovascular and urogenital. The present study aimed to explore the genome-wide effects of MAML1 on gene expression and DNA methylation in human em...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-62177 | biostudies-arrayexpress
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