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ProteomicsSPE optimization for peptide sample preparation for urine peptidomics
Development of a modified solid phase extraction (SPE) approach for improved peptide yield and analysis sensitivity with LC-MS based peptidomics of urine.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-23 | MSV000080086 | MassIVE
TranscriptomicsIdentification and Characterization of the Mammalian Nuclear RNA N6-Adenosine Methyltransferase Core Complex
N6-methyladenosine (m6A) is the most prevalent internal modification found in mammalian messenger and non-coding RNAs. The discoveries of functionally significant demethylases that reverse this methylation as well as the recently revealed m6A distributions in mammalian transcriptomes strongly indica...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-46705 | biostudies-arrayexpress
GenomicsSelective chemical labeling reveals intragenic enrichment of 5-hydroxymethylcytosine in mouse cerebellum
5-Methylcytosine (5-mC) is an important DNA modification found in eukaryotes that impacts gene regulation and disease pathogenesis. Recently, 5-hydroxymethylcytosine (5-hmC), another form of DNA modification, has been identified in substantial amounts in certain mammalian cell types; however, its ro...
ORGANISM(S): Mus musculus 
2010-12-12 | E-GEOD-25398 | biostudies-arrayexpress
MetabolomicsNon-invasive urinary metabolomic profiles discriminate biliary atresia from infantile hepatitis syndrome
INTRODUCTION: Neonatal cholestatic disorders are a group of hepatobiliary diseases occurring in the first 3 months of life. The most common causes of neonatal cholestasis are infantile hepatitis syndrome (IHS) and biliary atresia (BA). The clinical manifestations of the two diseases are ...
2019-06-25 | MTBLS689 | MetaboLights
UnknownSampling inequalities affect generalization of neuroimaging-based diagnostic classifiers in psychiatry.
Not available
S-EPMC10318841 | biostudies-literature
TranscriptomicsGene Expression Test for Operational Renal Allograft Tolerance
Genomic Analysis of more than 400 patients from multi-center transplant programs and clinical trials provides a non-invasive QPCR based gene expression test for operational renal allograft tolerance 3 group comparison of blood from TOL, CAN and Non-transplant healthy controls (HD) allografts. Biolog...
ORGANISM(S): Homo sapiens 
2015-01-08 | E-GEOD-45218 | biostudies-arrayexpress
ProteomicsPTMC_The proteomic profiles of pyridinium-based strategy for lysine-selective protein modification in live cells
A new bioorthogonal lysine-labeling strategy based on cationic-pyridinium activated ester, which renders the modification of peptides and proteins’ lysine residues with ultrafast kinetics and excellent specificity under aqueous solution, and profiled reactive-lysine proteome in vitro and in live cel...
ORGANISM(S): Homo Sapiens 
2023-10-24 | PXD036388 |
Transcriptomicsm1A marks translation initiation sites in human and mouse messenger RNA [Sequencing]
We developed a novel approach, m1A-seq, for high-resolution mapping of the transcriptome-wide m1A landscape, based on antibody-mediated capture followed by massively parallel sequencing Identification of m1A modified sequences in human, mouse and yeast cell lines
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-70485 | biostudies-arrayexpress
Transcriptomicsm1A marks translation initiation sites in human and mouse messenger RNA [microarray]
We developed a novel approach, m1A-seq, for high-resolution mapping of the transcriptome-wide m1A landscape, based on antibody-mediated capture followed by massively parallel sequencing. Using this method we performed immunodepletion of methylated transcipts to assess the average methylation level I...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76057 | biostudies-arrayexpress
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
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