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GenomicsThe alteration of 5-hydroxymethylcytosine modification contributes to ischemic brain injury [5hmC-seq]
Epigenetic modifications, such as cytosine methylation and histone modification, have been shown involved in the pathology of ischemic brain injury. Recent works have implicated 5-hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC) through the oxidation by Ten-Eleven Translo...
ORGANISM(S): Mus musculus 
2015-09-08 | E-GEOD-67188 | biostudies-arrayexpress
UnknownJian-Pi-Yi-Shen formula improves kidney function by regulating gut microbiome in rats with chronic kidney disease.
Not available
S-EPMC12283701 | biostudies-literature
UnknownEthnic disparities in stillbirth risk in Yunnan, China: a prospective cohort study, 2010-2018.
Not available
S-EPMC7807874 | biostudies-literature
UnknownFast surface reconstruction algorithm with adaptive step size.
Not available
S-EPMC11771931 | biostudies-literature
ProteomicsUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD045622 | Pride
Usp36  snail1  ribosome biogenesis  ribotoxic stress 
TranscriptomicsCombined loss of Tet1 and Tet2 promotes B-cell, but not myeloid malignancies in mice
TET1/2/3 are methylcytosine dioxygenases regulating cytosine hydroxymethylation in the genome. Tet1 and Tet2 are abundantly expressed in HSC/HPCs and implicated in the pathogenesis of hematological malignancies. Tet2-deletion in mice causes myeloid malignancies, while Tet1-null mice develop B-cell l...
ORGANISM(S): Mus musculus 
2015-11-12 | E-GEOD-73611 | biostudies-arrayexpress
UnknownMetabolomic analysis and pharmacological validation of the cerebral protective effect of 3,4‑dihydroxybenzaldehyde on cerebral ischemia‑reperfusion injury.
Not available
S-EPMC9685269 | biostudies-literature
UnknownNetwork pharmacology and molecular docking analysis on molecular targets and mechanisms of Gastrodia elata Blume in the treatment of ischemic stroke.
Not available
S-EPMC9764286 | biostudies-literature
UnknownThe complete chloroplast genome of Tibetia liangshanensis P. C. Li (Leguminosae: Papilionoideae), an endemic species of China.
Not available
S-EPMC8189137 | biostudies-literature
UnknownA novel mutation of COL2A1 in a large Chinese family with avascular necrosis of the femoral head.
Not available
S-EPMC8178877 | biostudies-literature
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