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TranscriptomicsThe role of PCNA ubiquitylation during unperturbed genome replication in S.pombe
To establish if PCNA ubiquitylation affects the DNA replication kinetics of specific loci, we compared rates of DNA replication across the genome between rad18+ and rad18-delta cells using the BrdU-IP sequencing method. We mapped BrdU-incorporation at 300-bp resolution and subsequent informatics an...
ORGANISM(S): Schizosaccharomyces pombe 
2017-05-12 | E-GEOD-70033 | biostudies-arrayexpress
TranscriptomicsA global profile of replication polymerase usage
We have established a novel sequencing approach to characterise usage of replicative DNA polymerases in S. pombe. This approach allows us to determine the roles of DNA polymerase delta and epsilon in lagging strand and leading strand DNA synthesis, respectively in genome-wide scale. Utilising the d...
ORGANISM(S): Schizosaccharomyces pombe 
2015-02-03 | E-GEOD-62108 | biostudies-arrayexpress
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