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MetabolomicsM12-24 metabolome of dairy cow

This study conducted non-targeted metabolomic analysis on rumen fluid from 24 dairy cows fed with M12 additive, aiming to comprehensively profile changes in endogenous metabolites and elucidate the mechanism by which M12 modulates rumen function.

2025-10-21 | MTBLS12930 | MetaboLights
MetabolomicsEffect of chromium propionate supplementation in prepartum dairy cow diets on neonatal oxidative stress in calves: a multi-omics investigation

Background:

Neonatal oxidative stress at birth in calves represents a significant challenge for livestock farmers, directly affecting calf survival, health status and subsequent growth performance. Chromium propionate (CrPro), a chelate formed between propionate and Trivalent chromium [Cr (...

2025-03-21 | MTBLS12340 | MetaboLights
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
MetabolomicsPlasma metabolome alteration in dairy cows with left displaced abomasum before and after surgical correction
Left displaced abomasum (LDA) leads to substantial changes in the metabolism of dairy cows. Surgical correction of LDA can rapidly improve the health of cows; however, changes in metabolism following surgery are rarely described. To investigate the changes of plasma metabolome in cows with LDA befor...
2022-08-17 | MTBLS4126 | MetaboLights
MetabolomicsAltered Fecal Microbiome and Correlations of the Metabolome with Plasma Metabolites in Dairy Cows with Left Displaced Abomasum

Left displaced abomasum (LDA) in postpartum dairy cows contributes to significant economic losses. LDA is characterized by excessive lipolysis and insulin resistance. Although gut dysbiosis is implicated, little is known about the role of the gut microbiota in the abnormal metabolic processes of ...

2022-08-17 | MTBLS2441 | MetaboLights
MetabolomicsMulti-omics and intervention analyses reveal a hindgut microbiota–secondary bile acid–mammary axis linked to milk yield in dairy cows_serum

Shotgun metagenomics, untargeted metabolomics, and targeted metabolomics of high versus normal-yield cows revealed that high-yield animals harbored distinct hindgut microbial communities enriched in bile salt hydrolase–positive taxa, and elevated levels of deoxycholic acid (DCA). Fecal microbiota...

2026-04-15 | MTBLS14061 | MetaboLights
MetabolomicsLactation-related metabolic mechanism investigated based on mammary gland metabolomics and 4 biofluids’ metabolomics relationships in dairy cows

BACKGROUND: Lactation is extremely important for dairy cows; however, the understanding of the underlying metabolic mechanisms is very limited. This study was conducted to investigate the inherent metabolic patterns during lactation using the overall biofluid metabolomics and the...

2018-03-16 | MTBLS411 | MetaboLights
MetabolomicsMetabolomic profiling of cow-based bioformulations used in sustainable agriculture: Jeevamrit and Ghanjeevamrit

Jeevamrit (JV) and Ghanjeevamrit (GH) are traditional cow-based bioformulations used in natural farming practice, and this study provides a comprehensive characterization of metabolite profiles via GC-MS, and LC-MS analysis. Untargeted metabolomics revealed ~222 (GC-MS) and ~104...

2025-12-11 | MTBLS13493 | MetaboLights
MetabolomicsPlasma metabolite changes in dairy cows during parturition identified using untargeted metabolomics
The metabolic responses of cows undergo substantial changes during the transition from late pregnancy to early lactation. However, the molecular mechanisms associated with these changes in physiological metabolism have not been clearly elucidated. The objective of this study was to investigate metab...
2019-08-20 | MTBLS809 | MetaboLights
MetabolomicsColostrum metabolomic profiling of periparturient dairy cows supplemented with high-dose chromium propionate before calving
This study contains untargeted LC-MS/MS metabolomic profiles of colostrum samples collected at the first milking after calving from Holstein dairy cows in the control and high-dose chromium propionate supplementation groups. Cows received either a basal total mixed ration without supplemental chromi...
2026-09-26 | MTBLS15562 | MetaboLights
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