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TranscriptomicsExpression changes in MEL cells upon differentiation and Ldb1 knockdown
Carbonic anhydrase 1 (Car1), an early specific marker of the erythroid differentiation, has been used to distinguish fetal and adult erythroid cells since its production closely follows the γ- to β-globin transition, but the molecular mechanism underlying transcriptional regulation of Car1 is unclea...
ORGANISM(S): Mus musculus 
2012-12-11 | E-GEOD-42839 | biostudies-arrayexpress
TranscriptomicsCell type specificity of chromatin organization mediated by CTCF and cohesin
CTCF sites are abundant in the genomes of diverse species but their function is enigmatic. We used chromosome conformation capture to determine long-range interactions among CTCF/cohesin sites over 2 Mb on human chromosome 11 encompassing the β-globin locus and flanking olfactory receptor genes. Alt...
ORGANISM(S): Homo sapiens 
2011-01-13 | E-GEOD-26507 | biostudies-arrayexpress
TranscriptomicsGenome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila
Chromatin insulators are functionally conserved DNA-protein complexes that are situated throughout the genome and organize independent transcriptional domains.  Previous work implicated RNA as an important cofactor in chromatin insulator activity, although the mechanisms by which RNA affects insulat...
ORGANISM(S): Drosophila melanogaster 
2013-01-29 | E-GEOD-41950 | biostudies-arrayexpress
TranscriptomicsDistinct Ldb1/NLI complexes orchestrate γ-globin repression and re-activation through ETO2 in human adult erythroid cells.
The Ldb1/GATA-1/TAL1/LMO2 complex mediates long range interaction between the β-globin locus control region (LCR) and gene in adult mouse erythroid cells but whether this complex mediates chromatin interactions at other developmental stages or in human cells is unknown. We investigated human NLI (Ld...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-30047 | biostudies-arrayexpress
GenomicsLdb1-nucleated transcription complexes function as primary mediators of erythroid gene activation
We used ChIP-Seq to map Ldb1, Scl and Gata1 binding sites in mouse total bone marrow cells. Together with functional studies comparing gene expression in Murine Erythroleukemia (MEL) cells expressing Ldb1 shRNA or control shRNA and bioinformatics analysis, we systematically determined the transcrip...
ORGANISM(S): Mus musculus 
2013-04-29 | E-GEOD-42843 | biostudies-arrayexpress
UnknownCPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.
Not available
S-EPMC6127025 | biostudies-literature
TranscriptomicsMessenger RNA is a functional component of a chromatin insulator complex
Chromatin insulators are DNA-protein complexes situated throughout the genome capable of demarcating independent transcriptional domains. Previous studies point to an important role for RNA in gypsy chromatin insulator function in Drosophila; however, the identity of these putative insulator-associa...
ORGANISM(S): Drosophila melanogaster 
2013-08-06 | E-GEOD-29991 | biostudies-arrayexpress
TranscriptomicsRNA-Seq on Illumina platform of Drosophila DrosDel deficiency lines
RNA-Seq reads of DrosDel deficiency (Df/+) and parental strain diploid flies along with spike-in controls was performed on the Illumina platform. Samples are named in this dataset according to the following sample naming scheme: tissue_genotype shorthand_sex_biological replicate #_platform. We seque...
ORGANISM(S): Drosophila melanogaster 
2012-04-03 | E-GEOD-31549 | biostudies-arrayexpress
TranscriptomicsRNA-Seq on SOLiD platform of DrosDel deficiency and w1118 flies
RNA-Seq reads of DrosDel deficiency (Df/+) and parental strain diploid flies along with spike-in controls was performed on the SOLiD platform. Samples are named in this dataset according to the following sample naming scheme: tissue_genotype shorthand_sex_biological replicate #_platform_technical re...
ORGANISM(S): Drosophila melanogaster 
2012-04-03 | E-GEOD-31401 | biostudies-arrayexpress
UnknownThe Political Consequences of Latino Prejudice against Blacks.
Not available
S-EPMC4888580 | biostudies-literature
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