Sort   by:  
 Page size 
TranscriptomicsRNA-seq of mouse cortical tissue and astrocytes after anesthesia and induction of neuronal activity
General anesthesia is a common clinical procedure yet can result in long term CNS-adverse effects, particularly in the elderly, or dementia patients. Suppression of cortical activity is a key feature of the anesthetic-induced unconscious state, with activity being a well-described regulator of pathw...
ORGANISM(S): Mus musculus 
2023-08-01 | E-MTAB-13054 | biostudies-arrayexpress
TranscriptomicsRNA-seq of rat microglia, mouse neurons and human astrocytes in co-culture, challenged with different concentrations of LPS - dataset 2
We investigated non-cell-autonomous regulation of gene expression in microglia by neurons and astrocytes, by co-culturing these cell types (derived from different mammalian species) together, and then separating the RNA-seq reads from each cell type/species in silico. This submission forms a compani...
ORGANISM(S): mixed sample 
2021-03-23 | E-MTAB-7776 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of rat microglia in monoculture and in coculture with neurons and astrocytes
Microglia, brain resident macrophages, require instruction from the central nervous system microenvironment to maintain their identity, morphology, and to regulate inflammatory responses. We investigated the heterogeneity of response of microglia to the presence of neurons and astrocytes by performi...
ORGANISM(S): Rattus norvegicus 
2021-03-23 | E-MTAB-10030 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse astrocytes in monoculture and co-cultured with rat neurons (both inactive and active).
Neurons induce a dramatic transformation in developing astrocytes, causing them to develop a complex stellate morphology resembling their appearance in vivo. However, the transcriptional changes that accompany this transformation are not known, nor are the signalling mechanisms responsible. Similarl...
ORGANISM(S): Rattus norvegicus 
2017-05-02 | E-MTAB-5514 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human and mouse stem-cell derived neurons and mouse primary cortical neurons after KCl-induced membrane depolarization against controls.
This experiment comprises RNA-seq data used to study evolutionary differences between humans and mice in neuronal activity-dependent transcriptional responses. Activity-dependent transcriptional responses in developing human stem cell-derived cortical neurons were compared with those induced in deve...
ORGANISM(S): Mus musculus 
2017-02-16 | E-MTAB-5489 | biostudies-arrayexpress
TranscriptomicsWhole cortex and brain endothelial cell-specific RNA-seq of mice subjected to peripherally-induced inflammation
The blood-brain barrier is an interface for signal exchange between the brain and the periphery. We reasoned that brain endothelial cells (BECs) are ideally positioned to receive signals from the blood and transduce them into the brain via direct communication with astrocyte endfeet. In combination ...
ORGANISM(S): Mus musculus 
2025-09-09 | E-MTAB-14490 | biostudies-arrayexpress
TranscriptomicsRNA-seq of triple cultures of neurons, astrocytes and microglia treated with blood clot conditioned media, lipopolysaccharide, and Nrf2-activating drug CDDO-TFEA.
Secondary injury causes death and dependence after spontaneous intracerebral haemorrhage (ICH). We found that myelomononuclear Nrf2 is active and protective after ICH in mice. To investigate the roles of myelomononuclear Nrf2 in modulating cell autonomous and non-cell autonomous responses to the oxi...
ORGANISM(S): mixed sample 
2024-08-13 | E-MTAB-14327 | biostudies-arrayexpress
UnknownSafety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial.
Not available
S-EPMC7674972 | biostudies-literature
Sort   by:  
 Page size