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TranscriptomicsTranscription profiling of mouse liver to assess the translational response following activation of GCN2 versus PERK - super series
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11685 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Gcn2 wild-type and knockout liver perfused with or without methionine
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11496 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Perk wild-type and knockout liver perfused without or with 2,5-di-tert-butylhydroquinone
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11684 | biostudies-arrayexpress
TranscriptomicsWnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.
We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond to therapeutic stress by increasing p21 an...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-50004 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of inducible ES cells overexpressing Etv2 (induced for 12 hours at day 3 of differentiation)
During embryogenesis, the endothelial and the hematopoietic lineages first appear during gastrulation in the blood island of the yolk sac. We have previously reported that an Ets variant gene 2 (Etv2/ER71) mutant embryo lacks hematopoietic and endothelial lineages, however, the precise roles of Etv2...
ORGANISM(S): Mus musculus 
2012-07-03 | E-GEOD-37658 | biostudies-arrayexpress
UnknownAntimicrobial and alpha-glucosidase inhibitory flavonoid glycosides from the plant Mussaenda recurvata: in vitro and in silico approaches.
Not available
S-EPMC10950057 | biostudies-literature
TranscriptomicsCompensatory IKKa activation of classical NF-kB signaling during IKKb inhibition
A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive NF-kB pathway signaling for survival. Small molecule inhibitors of IkB kinase b (IKKb), a key regulator of the NF-kB pathway, kill ABC DLBCL cells and hold promise for the treatment ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-11902 | biostudies-arrayexpress
UnknownBrain proton MR spectroscopy measurements in CLN3 disease.
Not available
S-EPMC10202445 | biostudies-literature
UnknownEstablishment of an in-house real-time RT-PCR assay for the detection of severe acute respiratory syndrome coronavirus 2 using the first World Health Organization international standard in a resource-limited country.
Not available
S-EPMC9102516 | biostudies-literature
UnknownElevated oxysterol and N-palmitoyl-O-phosphocholineserine levels in congenital disorders of glycosylation.
Not available
S-EPMC10023375 | biostudies-literature
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