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ProteomicsDivergent Cysteines in FOXO3 and FOXO4 Mediate Paralog-Specific Redox Signaling
Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is mediated by the reversible oxidation of specific cysteine thiols. The latter results in disulfide formation between protein (hetero)dimers that alter protein function until t...
ORGANISM(S): Homo sapiens (Human) 
2014-08-26 | PXD001018 | Pride
Foxo cysteine-dependent interactors 
ProteomicsDivergent Cysteines in FOXO3 and FOXO4 Mediate Paralog-Specific Redox Signaling
Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is mediated by the reversible oxidation of specific cysteine thiols. The latter results in disulfide formation between protein (hetero)dimers that alter protein function until t...
ORGANISM(S): Homo sapiens (Human) 
2014-08-26 | PXD001040 | Pride
Foxo3 human redox 
ProteomicsDivergent Cysteines in FOXO3 and FOXO4 Mediate Paralog-Specific Redox Signaling
Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is mediated by the reversible oxidation of specific cysteine thiols. The latter results in disulfide formation between protein (hetero)dimers that alter protein function until t...
ORGANISM(S): Homo sapiens (Human) 
2014-08-26 | PXD001041 | Pride
Foxo3 reduction-oxidation (redox) signaling 
ProteomicsCysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A
p16INK4A inhibits the CDK4/6 kinases and is therefore an important cell cycle regulator. Accumulation of p16INK4A in response to oncogenic transformation leads to cellular senescence and it is therefore frequently lost in cancer. p16INK4A is also known to accumulate under conditions of cellular oxid...
ORGANISM(S): Homo sapiens (Human) 
2019-09-04 | PXD012353 | Pride
Cysteine oxidation amyloid fibril p16ink4a 
ProteomicsThe Human 2-Cys Peroxiredoxins Form Widespread, Cysteine-Dependent- And Isoform-Specific Protein-Protein Interactions.
Redox signaling is controlled by the reversible oxidation of cysteine thiols, a post-translational modification triggered by H2O2 acting as a second messenger. However, H2O2 reacts poorly with most cysteine thiols and it is not clear how it discriminates between cysteines to trigger appropriate sign...
ORGANISM(S): Homo sapiens (Human) 
2021-05-04 | PXD024114 | Pride
Protein thiol oxidation Cysteine sulfenic acid Hydrogen peroxide Thiol disulfide exchange Peroxiredoxin  redox signaling  redox relay 
TranscriptomicsTranscription profiling of human embryonic kidney cell line HEK293T to investigate the effects of overexpression of FoxO4 or mutated FoxO4 in presence or absence of p300
Effects of overexpression of FoxO4 or mutated FoxO4 in presence or absence of p300 overexpression
ORGANISM(S): Homo sapiens 
2009-07-30 | E-MTAB-4 | biostudies-arrayexpress
OtherEvolutionary Acquisition of Cysteines determines FOXO Paralog-Specific Redox Signaling
Data from ProteomeXchange, PXD ID: PXD001018. Experiment: HRV_A, file: folder summary. Published as part of Antioxid Redox Signal. 2014 Jul 29 . From the Abstract: {{i}} Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is med...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320002469 | GPMDB
Resource Reanalysis 
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