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ProteomicsItaconate modulates immune responses via inhibition of peroxiredoxin 5
Wild type and Irg1 knockout mouse bone marrow derived macrophages (BMDMs) were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-01 | MSV000093232 | MassIVE
MetabolomicsRedox proteomics reveal a role for peroxiredoxinylation in stress protection.

The redox state of proteins is essential for their function and guarantees cell fitness. Peroxiredoxins protect cells against oxidative stress, maintain redox homeostasis, act as chaperones, and transmit hydrogen peroxide signals to redox regulators. Despite the profound structural and functional...

2025-07-17 | MTBLS11979 | MetaboLights
TranscriptomicsRNA-Seq of human skeletal muscle cell line AB1167, with groups of PRDX2 KD, treated with electrical stimulation and both 2.5 and 5uM H202 for 15 minutes
This study investigates the role of peroxiredoxin 2 (PRDX2) in mediating oxidative adaptations in human skeletal muscle myotubes subjected to mechanical contraction and hydrogen peroxide (H2O2) exposure. additionally, the effect of an electrical stimulation protocol was assessed pre and post PRDX2 K...
ORGANISM(S): Homo sapiens 
2025-01-01 | E-MTAB-14577 | biostudies-arrayexpress
GenomicsThe peroxiredoxin Asp f3 acts as redox sensor in Aspergillus fumigatus
The peroxiredoxin Asp f3 acts as redox sensor in Aspergillus fumigatus
PRJNA725214 | ENA
ProteomicsPeroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape, secretome analysis
Cellular senescence is a complex stress response defined as an essentially irreversible cell cycle arrest mediated by the inhibition of cell cycle-specific cyclin dependent kinases. The imbalance in redox homeostasis and oxidative stress have been repeatedly observed as one of the hallmarks of the s...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028772 | Pride
Secretome analysis Peroxiredoxin 6 Cellular senescence Dia Exploris Ionizing radiation 
ProteomicsPeroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape, redox proteomic analysis
Cellular senescence is a complex stress response defined as an essentially irreversible cell cycle arrest mediated by the inhibition of cell cycle-specific cyclin dependent kinases. The imbalance in redox homeostasis and oxidative stress have been repeatedly observed as one of the hallmarks of the s...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028780 | Pride
Peroxiredoxin 6 Cellular senescence Silac-iodotmt Ionizing radiation Redox proteomics 
ProteomicsPeroxiredoxin 1 protects telomeres from oxidative damage preserving chromosome ends for extension by telomerase
With the increase of atmospheric oxygen 2.3 billion years ago, mechanisms evolved to mitigate the toxic effects of oxygen radicals. Telomeres appear particularly susceptible to oxidative damage, which leads to cellular and organismal aging, cancer, cardiac failure and other diseases. Specific mechan...
ORGANISM(S): Homo sapiens (Human) 
2016-12-07 | PXD002626 | Pride
Peroxiredoxin 1  telomeres  oxidative damage  telomerase 
GenomicsTargeting peroxiredoxin 2 prevents hepatocarcinogenesis in metabolic liver disease models
Targeting peroxiredoxin 2 prevents hepatocarcinogenesis in metabolic liver disease models
PRJNA819391 | ENA
ProteomicsGlobal proteomics of Peroxiredoxin 6 knockdown A549 cells subjected to ionizing radiation
In this project, we have performed global proteomics of A549 lung cancer cells subjected to Peroxiredoxin 6 knockdown, 4Gy ionizing or combination of both. The aim of the project is to find out proteome level alterations in PRDX6KD cell which make them sensitive to ionizing radiation mediated cell d...
ORGANISM(S): Homo sapiens (Human) 
2026-08-02 | PXD076585 | Pride
Ferroptosis A549 Nsclc Peroxiredoxin Radiation. 
ProteomicsLight-sensing via H2O2 and a peroxiredoxin
Light controls control a vast array of biological processes, including cell and organelle motility, stress responses, organismal development and the entrainment of circadian rhythms, that maintain diurnal cycles of activity in organisms from cyanobacteria to humans. Recent studies indicate that a ty...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-07-03 | PXD001853 | Pride
Lc-msms Yeast H2o2 Oxidative stress Msn2 
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