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TranscriptomicsDaptomycin stimulon in Bacillus subtilis W168
Abstract of associated manuscript: Daptomycin is the first of a new class of cyclic lipopeptide antibiotics used against multidrug-resistant Gram-positive pathogens. The proposed mechanism of action involves disruption of the functional integrity of the bacterial membrane in a Ca2+-dependent manner....
ORGANISM(S): Bacillus subtilis 
2008-12-10 | E-GEOD-13900 | biostudies-arrayexpress
ProteomicsFPOP of Daptomycin in Nanodiscs
FPOP data examining solvent exposure of daptomycin at different concentrations in the presence of nanodiscs with different lipids
ORGANISM(S): Bacteria (ncbitaxon:2) 
2022-11-01 | MSV000090629 | MassIVE
TranscriptomicsDaptomycin-Resistance Mechanisms in Clinically-Derived Staphylococcus aureus Strains Assessed by a Combined Transcriptomics and Proteomics Approach
Objectives: Development of daptomycin resistance (DAPR) in Staphylococcus aureus is associated with clinical treatment failures. Mechanism(s) of such resistance has not been clearly defined. Methods: We studied an isogenic daptomycin-susceptible (DAPS) and daptomycin-resistant (DAPR) S. aureus stra...
ORGANISM(S): Staphylococcus aureus 
2011-12-02 | E-GEOD-28632 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Daptomycin resistance in Stapyloccoccus aureus strains: 2818 and 2819.
The study aims to identify genes associated with daptomycin resistance. Samples were hybridized on aminosilane coated slides with 70-mer oligos.
ORGANISM(S): Staphylococcus aureus 
2011-04-08 | E-GEOD-26249 | biostudies-arrayexpress
TranscriptomicsA mutation in PP2C Phosphatase Gene in a Staphylococcus aureus USA300 Clinical Isolate with Reduced Susceptibility to Vancomycin and Daptomycin
Investigation of baseline transcription activity of two different clinical isolates of Staphylococcus aureus with two different susceptibility levels to the antibiotics Vancomycin and Daptomycin. Two different strains of Staphylococcus aureus, one that is fully Vancomycin and Daptomycin Sensitive an...
ORGANISM(S): Staphylococcus aureus 
2012-08-03 | E-GEOD-39868 | biostudies-arrayexpress
ProteomicsProteomic Investigation of Multiple Methicillin-Resistant Staphylococcus aureus strains with distinct Daptomycin Tolerance and Resistance Phenotypes
Several groups have shown that through evolution experiments, tolerance and resistance evolved rapidly under cyclic antibiotic treatment. In other words, intermittent antibiotic exposure performed in a typical adaptive laboratory evolution (ALE) experiments will “train” the bacteria to become tolera...
ORGANISM(S): Staphylococcus aureus 
2022-07-14 | PXD026741 | Pride
Proteomics Daptomycin Methicillin-resistant staphylococcus aureus Adaptive laboratory evolution Tolerance 
TranscriptomicsReduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis
Transcriptional response of Bacillus subtilis to daptomycin in wild-type and in a daptomycin resistant mutant. Bacillus subtilis 168, WT (-DAP) vs. DapR1 (-DAP), WT (+DAP) vs. DapR1 (+DAP), DapR1 (+DAP) vs. DapR1 (-DAP). Each experiment was conducted at least twice using two independent total RNA pr...
ORGANISM(S): Bacillus subtilis 
2011-06-16 | E-GEOD-30000 | biostudies-arrayexpress
TranscriptomicsMetabolic and transcriptional activities of Staphylococcus aureus challenged with high-doses of daptomycin
Treatment of stationary growth phase Staphylococcus aureus SA113 with 100-fold of the MIC of the lipopeptide antibiotic daptomycin leaves alive a small fraction of drug tolerant albeit genetically susceptible bacteria. This study shows that cells of this subpopulation exhibit active metabolism even ...
ORGANISM(S): Staphylococcus aureus 
2014-06-06 | E-GEOD-57908 | biostudies-arrayexpress
ProteomicsProteomic Investigation of Evolved Daptomycin-Tolerant MRSA due to Mutation in YycH
Several groups have shown that through evolution experiments, tolerance and resistance evolved rapidly under cyclic antibiotic treatment. In other words, intermittent antibiotic exposure performed in a typical adaptive laboratory evolution (ALE) experiments will “train” the bacteria to become tolera...
ORGANISM(S): Staphylococcus aureus 
2022-07-16 | PXD031078 | Pride
Proteomics Daptomycin Methicillin-resistant s. aureus Adaptive laboratory evolution Tolerance Yych 
TranscriptomicsSwitching on antibiotic resistance in Staphylococcus aureus M-bM-^@M-^S Contribution of WalK and VraS histidine kinases in the development of vancomycin and daptomycin resistance
Staphylococcus aureus is a notorious bacterial pathogen that causes a broad range of human diseases, and isolates that are resistant to several antibiotic classes including last resort antibiotics like vancomycin and daptomycin complicate the situation. We characterized S. aureus VC40, a strain that...
ORGANISM(S): Staphylococcus aureus subsp. aureus Mu50 
2014-08-18 | E-GEOD-46887 | biostudies-arrayexpress
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