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ProteomicsTargeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses in bacterial pneumonia
The severity of bacterial pneumonia can be worsened by impaired innate immunity resulting in ineffective pathogen clearance. Here We describe a mitochondrial protein, aspartyl-tRNA synthetase (DARS2), which is released in circulation during bacterial pneumonia in humans and displays intrinsic innate...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050224 | Pride
Inflammation Pneumonia Dars2 
GenomicsTranscriptomic profiling of a CamKII-Dars2 neuronal knockout mouse
Transcriptomic profiling of a CamKII-Dars2 neuronal knockout mouse
PRJNA591892 | ENA
GenomicsDars2 is involved in mRNA splicing in mouse bone marrow hematopoietic stem and progenitor cells
Dars2 is involved in mRNA splicing in mouse bone marrow hematopoietic stem and progenitor cells
PRJNA883254 | ENA
TranscriptomicsTranscriptomic profiling of a CamKII-Dars2 neuronal knockout mouse
Purpose: Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL) is a rare, slowly progressive white matter disease caused by mutations in the mitochondrial aspartyl-tRNA synthetase (DARS2). While patients show characteristic MRI T2 signal abnormalities throughou...
ORGANISM(S): Mus musculus 
2020-02-04 | GSE141055 | GEO
TranscriptomicsDars2 is involved in mRNA splicing in mouse bone marrow hematopoietic stem and progenitor cells
Deletion of Dars2 in HSPCs largely impairs spliceosome function and suppresses the protein expression of Srsf3.We performed high-coverage mRNA-seq on lin- ckit+ (LK) cells from both WT and Dars2-KO mice, respectively, to characterize genome-wide alternative splicing (AS) events affected in Dars2-KO ...
ORGANISM(S): Mus musculus 
2023-09-25 | GSE213952 | GEO
UnknownPrognostic biomarker DARS2 correlated with immune infiltrates in bladder tumor.
Not available
S-EPMC10827901 | biostudies-literature
GenomicsmRNAseq and proteomic data set of one week old WT (Chop wt/wt CkmmCre wt/wt Dars2 fl/fl), Chop KO (Chop ko/ko CkmmCre wt/wt Dars2 fl/fl), Dars2 KO (Chop wt/wt CkmmCre tg/wt Dars2 fl/fl) and DKO (Chop ko/ko CkmmCre tg/wt Dars2 fl/fl) mice
mRNAseq and proteomic data set of one week old WT (Chop wt/wt CkmmCre wt/wt Dars2 fl/fl), Chop KO (Chop ko/ko CkmmCre wt/wt Dars2 fl/fl), Dars2 KO (Chop wt/wt CkmmCre tg/wt Dars2 fl/fl) and DKO (Chop ko/ko CkmmCre tg/wt Dars2 fl/fl) mice
PRJNA627135 | ENA
UnknownA New DARS2 Mutation Discovered in an Adult Patient.
Not available
S-EPMC7154256 | biostudies-literature
UnknownDARS2 Promotes Bladder Cancer Progression by Enhancing PINK1-Mediated Mitophagy.
Not available
S-EPMC11844284 | biostudies-literature
UnknownDARS2 is a prognostic biomarker and correlated with immune infiltrates and cuproptosis in lung adenocarcinoma.
Not available
S-EPMC10077054 | biostudies-literature
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