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ProteomicsMechanisms of increased Alzheimer’s Disease pathology with R47H and R62H TREM2 variants
TREM2 plays multiple functional roles in microglia and variants are associated with increased risks of Alzheimer’s disease (AD). CD33 polymorphisms are protective. Here we have contrasted cellular pathology in human post mortem brain with and without AD to test mechanisms associated with the differ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD074536 | Pride
Brain Neurodegeneration Trem2 Alzheimer's disease 
ProteomicsPhosphoproteomic Survey of Human iPSC-derived Lung Alveolar Type 2 Cells Reveals Cytopathogenic Host Responses to SARS-CoV-2 Infection
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative pathogen of the coronavirus disease 2019 (COVID-19) pandemic, is exerting a massive health and socioeconomic burden. The virus infects pneumocytes, also known as alveolar epithelial type 2 (AT2) cells, ...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2020-11-20 | PXD020183 | Pride
Sars-cov-2 Mass spectrometry Human alveolar cells Drug targets Infection Phosphoproteomics Covid-19 Signaling Host pathways Pathogenesis Lung organoids 
TranscriptomicsPRPF8 CLIP seq for iPSC, kidney organoid, retinal organoid, and retinal epithelium derived from c.6926A>C RPE with Retinitis Pigmentosa patients and CRISPR/Cas9 corrected
Retinitis Pigmentosa is a group of inherited eye disorders characterized by progressive degeneration of photoreceptor cells in the retina, leading to vision loss and eventual blindness. One of the known genetic mutations associated with RP is the c.6926A>C mutation in the RPE (retinal pigment epithe...
ORGANISM(S): Homo sapiens 
2024-03-13 | E-MTAB-13171 | biostudies-arrayexpress
UnknownPrognostic factors for predicting outcomes after intramedullary nailing of the tibia.
Not available
S-EPMC3448300 | biostudies-literature
UnknownObesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study.
Not available
S-EPMC5464539 | biostudies-literature
UnknownThe REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.
Not available
S-EPMC5838871 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
Not available
S-EPMC8362594 | biostudies-literature
UnknownClinical practice selectively follows acute appendicitis guidelines.
Not available
S-EPMC9888346 | biostudies-literature
UnknownTechniques for mesoappendix transection and appendix resection: insights from the ESTES SnapAppy study.
Not available
S-EPMC9925585 | biostudies-literature
UnknownSurgical management of acute appendicitis during the European COVID-19 second wave: safe and effective.
Not available
S-EPMC9851576 | biostudies-literature
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