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TranscriptomicsExpression data from WT and TREM2 deficient microglia in a mouse model of Alzheimer's disease
We examined the role of TREM2 on microglia responses to amyloid-beta deposition in a mouse model of Alzheimer's disease Microglia were FACS-purified from 8.5 month old WT, Trem2-/-, 5XFAD, and Trem2-/- 5XFAD mice
ORGANISM(S): Mus musculus 
2015-03-13 | E-GEOD-65067 | biostudies-arrayexpress
TranscriptomicsTREM2 regulates microglial cell activation in response to demyelination in vivo
Microglia are phagocytic cells that survey the brain and perform neuroprotective functions in response to tissue damage, but their activating receptors are largely unknown. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in hum...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-70475 | biostudies-arrayexpress
ProteomicsTREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration
Triggering receptor expressed on myeloid cell 2 (TREM2) is linked to neurodegenerative disease risk. However, the function of TREM in neurodegeneration is still unclear. Here we investigated the role of microglial TREM2 in TAR-DNA binding protein 43 kDa (TDP-43)-related neurodegeneration using viral...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-12 | PXD029429 | Pride
Human Mouse Lc-ms/ms 
TranscriptomicsExpression data from WT and TREM2 deficient microglia in response to cuprizone mediated demyelination
We examined the role of TREM2 on microglia responses to demyelination Microglia were FACS-purified from WT or Trem2-/- mice fed with 0.2% cuprizone diet.
ORGANISM(S): Mus musculus 
2015-04-22 | E-GEOD-66926 | biostudies-arrayexpress
ProteomicsCSF and brain proteomics of Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI mice
Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer’s disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in ...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD065438 | Pride
Alzheimer's disease Csf Mouse Brain Trem2 Antibody treatment 
TranscriptomicsExpression data from wild type (WT) and TREM2 null alveolar macrophages (AM)
TREM-2 has been described to be a phagocytic receptor. We assessed the influence of TREM-2 on gene expression in alveolar macrophages (AM) In this data-set we characterised the differences in basal gene expression using affymetrix mouse 1.0 ST arrays between WT and TREM2-/- AM and observed TREM2 -/-...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-51378 | biostudies-arrayexpress
GenomicsscRNAseq profiling of myeloid and lymphoid cells in total Trem2+/+ and Trem2-/- lungs
scRNAseq profiling of myeloid and lymphoid cells in total Trem2+/+ and Trem2-/- lungs
PRJNA763923 | ENA
GenomicsTREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.
PRJNA1252464 | ENA
GenomicsTREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism
PRJNA1129559 | ENA
GenomicsscRNAseq profiling of lung myeloid cells in Trem2+/+ : Trem2-/- mixed bone marrow chimeric mice
scRNAseq profiling of lung myeloid cells in Trem2+/+ : Trem2-/- mixed bone marrow chimeric mice
PRJNA763932 | ENA
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