David Anna L AL

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Genomics (20)
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Homo sapiens (28)
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biostudies-arrayexpress (17)
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pride (2)
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2015 (6)
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2013 (2)
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2019 (2)
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CHEBI ID

CHEBI:17768 (3)
CHEBI:25094 (3)
CHEBI:18237 (3)
CHEBI:22660 (3)
CHEBI:22653 (3)
CHEBI:28300 (3)
CHEBI:25017 (3)
CHEBI:28044 (3)
CHEBI:17084 (3)
CHEBI:29016 (3)
CHEBI:90332 (2)
CHEBI:74767 (2)
CHEBI:134538 (2)
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CHEBI:64681 (2)
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CHEBI:37564 (2)
CHEBI:73027 (2)
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CHEBI:1606 (2)
CHEBI:191640 (2)

Metabolite Name

Cysteinylglycine disulfide* (2)
Prolylhydroxyproline (2)
4-hydroxycinnamate sulfate (2)
Ribulonate/xylulonate/lyxonate* (2)
5'- GMP (2)
Dihomolinoleate (20:2n6) (2)
2-palmitoleoyl-GPC* (16:1)* (2)
1-palmitoyl-GPI* (16:0) (2)
1-linoleoyl-GPI* (18:2)* (2)
1-arachidonoyl-GPI* (20:4)* (2)
Linoleoylcholine* (2)
Campesterol (2)
Propionylcarnitine (C3) (2)
Ascorbic acid 3-sulfate* (2)
3-amino-2-piperidone (2)
3-formylindole (2)
3-hydroxyoleoylcarnitine (2)
3-hydroxypalmitoylcarnitine (2)
2'-O-methyluridine (2)
Oleoylcholine (2)
Ascorbic acid 2-sulfate (2)
Isocitric lactone (2)
Palmitoylcholine (2)
1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0)* (2)
1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6)* (2)
1-oleoyl-2-docosahexaenoyl-GPC (18:1/22:6)* (2)
1-oleoyl-2-linoleoyl-GPE (18:1/18:2)* (2)
1-(1-enyl-palmitoyl)-2-linoleoyl-GPE (P-16:0/18:2)* (2)
1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4)* (2)
2-hydroxybutyrate/2-hydroxyisobutyrate (2)

Study type

Transcription profiling by array (11)
Methylation profiling by array (2)
RNA-seq of coding RNA (2)
Comparative genomic hybridization by array (1)
ChIP-seq (1)

Release Date

2015 (6)
2010 (3)
2008 (3)
2017 (2)
2011 (2)
2025 (2)
2024 (2)
2020 (2)
2014 (1)
2013 (1)
2016 (1)

Lab affiliation

IRCCS Istituto Ortopedico Galeazzi, Laboratorio di Applicazioni Biotecnologiche, Milan, Italy Department of Biomedical, Surgical and DentalSciences, Università degli Studi di Milano, Milan, Italy (1)
Research Centre for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia (1)

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Expression profile analysis of menin1 mutants

Expression analysis of Drosophila embryos with mnn overexpression, and adults with mnn deletion. Keywords: Expression analysis Described in Cerrato et al, Dev Biol. 2006 Oct 1;298(1):59-70.

ORGANISM(S): Drosophila melanogaster

2008-01-27 | E-GEOD-9425 | biostudies-arrayexpress

Proteomic analysis of extracellular vesicles and conditioned medium from human Adipose-derived Stem/Stromal Cells and Dermal Fibroblasts

Conditioned medium (CM) and extracellular vesicles (EV) from human Adipose-derived Stem/stromal cells (ASC) and Dermal fibroblasts (DF) can represent valid cell substitutes in regenerative medicine and other therapeutic applications. Whether one of the two cell products should be preferred over the ...

ORGANISM(S): Homo sapiens (Human)

2020-12-23 | PXD020219 | Pride

Obesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine serum assays)

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment and drive cancer could facilitate development...

2024-04-10 | MTBLS3316 | MetaboLights

Obesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine prostate assays)

2024-04-10 | MTBLS3317 | MetaboLights

Treatment of myeloma cell lines with the bromodomain inhibitor I-BET151

KMS12BM and H929 myeloma cells were treated in vitro with either I-BET151 1uM or vehicle (DMSO) for 6 hours (n=3 independent experiments for each cell line). Total RNA was extracted from H929 and KMS12BM cells using the RNeasy Mini kit (Qiagen). Genomic DNA contamination was eliminated using colum...

ORGANISM(S): Homo sapiens

2013-12-22 | E-MTAB-2122 | biostudies-arrayexpress

Direct on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights

The Mitochondrial Calcium Uniporter controls skeletal muscle mass in vivo

Muscle atrophy contributes to the poor prognosis of many physiopathological conditions, but pharmacological therapies are still limited. Muscle activity leads to major swings in mitochondrial [Ca2+] which control aerobic metabolism, cell death and survival pathways. We have investigated in vivo the ...

ORGANISM(S): Mus musculus

2015-03-05 | E-GEOD-60931 | biostudies-arrayexpress

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers Elovl2 as a novel regulator of glucose-induced insulin secretion

Defective insulin secretion by pancreatic Î² cells underlies the development of type 2 diabetes (T2D). High fat diet-fed mice are commonly used to study diabetes progression, but studies are usually limited to a single strain, such as C57Bl/6J. Here, we use a systems biology approach to integrate la...

ORGANISM(S): Mus musculus

2017-04-28 | E-GEOD-78183 | biostudies-arrayexpress

Crenigacestat inhibits osteogenic differentiation of human valve interstitial cells and seems promising for treatment of cardiovascular calcification

Vascular calcification is common pathology various forms of which presented in the half of humans. Calcific aortic valve disease (CAVD) is one of the most dangerous forms of vascular calcification. Despite high mortality there is no target therapy against CAVD. Thus, we tested crenigacestat (LY30394...

ORGANISM(S): Homo sapiens (Human)

2022-10-04 | PXD029632 | Pride

Valve intersticial cells Timstof pro Vascular calcification Ly3039478 Notch inhibitors Crenigacestat Calcific aortic valve disease Shotgun proteomics

CTL-OA-OP human IT PF Bone - CompuGen H19K microarray study

Aims of study: (1) To identify systemic differences in osteoarthritic (OA) bone that contribute to OA pathogenesis. (2) Identify novel osteoporotic (OP) bone-related disease genes. Study involved comparison of trabecular bone extracted from the intertrochanteric (IT) region of the proximal femur (PF...