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MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
UnknownPoly(trehalose methacrylate) as an Excipient for Insulin Stabilization: Mechanism and Safety.
Not available
S-EPMC9412841 | biostudies-literature
UnknownEvaluation of Posttraumatic Headache Phenotype and Recovery Time After Youth Concussion.
Not available
S-EPMC7941198 | biostudies-literature
TranscriptomicsGene expression profiling of laparoscopic donor nephrectomy samples compared to healthy control kidneys
We compared gene expression profiles from six donor kidneys prior to surgical manipulation to six kidneys removed after laparoscopic donor nephrectomy (LDN) and several hours of CO2 pneumoperitoneum. Biopsies were obtained from renal cortex and hybridized to Affymetrix HG-U133A GeneChips. For cont...
ORGANISM(S): Homo sapiens 
2005-09-14 | E-GEOD-3297 | biostudies-arrayexpress
UnknownRandomized Comparative Effectiveness Trial of 2 Federally Recommended Strategies to Reduce Excess Body Fat in Overweight, Low-Income Patients: MyPlate.gov vs Calorie Counting.
Not available
S-EPMC10202519 | biostudies-literature
ProteomicsLow-Dose CDK4/6 Inhibitors Induce Presentation of Pathway Specific MHC ligands as Potential Targets for Cancer Immunotherapy
Cyclin dependent kinase 4/6 inhibitors (CDK4/6i) lead to cell-cycle arrest but also trigger T cell-mediated immunity, which might be mediated by the qualitative and quantitative changes in human leukocyte antigen (HLA) ligands on the cancer cell surface. We investigated the effects of CDK4/6i, Abema...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024965 | Pride
Abemaciclib Palbociclib Breast cancer Cdk4/6 inhibition Mhc ligand 
ProteomicsProteomic analysis of adipocyte insulin resistance
Insulin resistance is a major risk factor for human metabolic diseases including type 2 diabetes, cardiovascular diseases and some cancers. We analysed the proteome analyses across in vitro and in vivo models of insulin resistance to find common features of insulin resistance and identified lower e...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-07 | PXD005128 | Pride
Insulin resistance Mouse Adipocyte Adipose tissue Orbitrap Lc-ms/ms 
ProteomicsHuman adipose insulin resistance
Adipocytes play a major role in whole body fuel homeostasis. Integrated proteomic analysis of adipose from insulin resistant versus healthy humans or mice or in 3T3-L1 adipocytes revealed defects in the mevalonate/coenzyme Q (CoQ) biosynthesis pathway as a unifying feature of adipocyte insulin resis...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD006891 | Pride
Human obese adipose tissue insulin resistance 
TranscriptomicsHypothalamic transcriptome plasticity in two rodent species reveals divergent differential gene expression but conserved pathways
We have addressed the question of how different rodent species cope with the life-threatening homeostatic challenge of dehydration at the level of transcriptome modulation in the supraoptic nucleus (SON), a specialised hypothalamic neurosecretory apparatus responsible for the production of the antid...
ORGANISM(S): Mus musculus 
2010-11-29 | E-GEOD-25574 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of the osmotic and reproductive remodelling of the female rat supraoptic nucleus
The supraoptic nucleus (SON) of the hypothalamus is an important integrative brain structure that co-ordinates responses to perturbations in water balance and regulates maternal physiology through the release of the neuropeptide hormones vasopressin and oxytocin into the circulation. Both dehydratio...
ORGANISM(S): Rattus norvegicus 
2011-12-29 | E-GEOD-30733 | biostudies-arrayexpress
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