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ProteomicsA 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in cancer
The remodeling of the extracellular matrix (ECM) by proteases releases fragments that promote tumor progression and metastasis. The protease cathepsin D (cath-D), a marker of poor prognosis in triple-negative breast cancer (TNBC), is aberrantly secreted in the ECM. Using degradomics, we discovered t...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022826 | Pride
Ecm Tnbc Protease Proteolysis Matricellular protein Tumor microenvironment 
TranscriptomicsA stemness-related ZEB1-MSRB3 axis governs cellular pliancy and cancer genome stability.
Genomic instability is a prominent driver of tumorigenesis. However, a significant fraction of human cancers display few genomic aberrations, suggesting alternative roads towards malignancy. Here, we show that the differentiation status of normal human mammary epithelial cells influences the early r...
ORGANISM(S): Homo sapiens 
2017-03-23 | E-MTAB-4145 | biostudies-arrayexpress
ProteomicsN-Myristoyltransferase inhibition in HeLa
N-Myristoyltransferase (NMT) covalently attaches a C14-fatty acid to the N-terminal glycine of proteins and has been proposed as a therapeutic target in cancer. We used quantitative proteomics to map protein expression changes for more than 2700 proteins in response to treatment with an NMT inhibito...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080783 | MassIVE
TranscriptomicsTranscription profiling of 57 hepato cellular carcinoma tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools
A ""Cartes d'Identite des Tumeurs"" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 65 samples on Affymetrix HG-U133A GeneChips arrays (57 tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools). Identification of six subgroups of Hepatocellular...
ORGANISM(S): Homo sapiens 
2007-03-26 | E-TABM-36 | biostudies-arrayexpress
GenomicsGabriel Consortium Data Access Committee
Access to summary data and individual-level genotype data is available by submitting a free form application to the Gabriel Consortium DAC. Access to data will be granted to qualified investigators for appropriate use.
EGAC00000000014 | EGA
ProteomicsFranco-Swiss HPP project (Chromosomes 2 and 14)
The dataset is a concatenation of nanoLC-MS/MS analyses performed on different sample types/sample preparations of human proteins on various instrumental platforms in the laboratory. A franco-swiss collaboration to identify missing human proteins on chromosomes 2 and 14 in the frame of the Human Pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080273 | MassIVE
GenomicsEGAD00000000076
Gabriel samples from the Australian Bussleton Cohort
EGAD00000000076 | EGA
GenomicsEGAD00000000090
Gabriel samples from the Russian KMSU cohort
EGAD00000000090 | EGA
GenomicsEGAD00000000106
Gabriel samples from the multicenter occupational cohort
EGAD00000000106 | EGA
GenomicsEGAD00000000087
Gabriel samples from the multicenter GAIN cohort
EGAD00000000087 | EGA
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