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ProteomicsProteomics Informed by Transcriptomics for Characterising Active Transposable Elements and Genome Annotation in Aedes aegypti
The incomplete genome annotation of non-model organisms hampers molecular and proteomic studies. Proteomics informed by transcriptomics (PIT) is suited to non-model organisms because peptides are identified using transcriptomic, not genomic, data. Aedes aegypti is the mosquito vector for the (re-)em...
ORGANISM(S): Aedes aegypti aegypti 
2017-02-15 | PXD003799 | Pride
Lc-ms/ms Pit Aedes aegypti Proteomics informed by transcriptomics 
UnknownA basal deuterostome genome viewed as a natural experiment.
Not available
S-EPMC2200295 | biostudies-literature
TranscriptomicsBASP1 modifies the Tamoxifen response
We report that WT1 transcriptional repressor protein BASP1 interacts with oestrogen receptor alpha (Erα), and interaction which in enhanced in the presence of Tamoxifen. We utilised RNASeq to identify common BASP1 and ERα target genes as well as Tamoxifen responsive genes that are altered in the a...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-78199 | biostudies-arrayexpress
ProteomicsEarly NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T...
ORGANISM(S): Homo sapiens (Human) 
2025-05-21 | PXD061694 | Pride
Dengue Cd4+ t-cells Cd8+ t-cells Co-inhibitory receptors Cytotoxic cells Severe dengue biomarkers Nk-cells Type-i ifn 
MetabolomicsCharacterisation of monophasic solvent-based tissue extractions for detection of polar metabolites and lipids applying UHPLC-MS clinical metabolic phenotyping assays

Metabolic phenotyping of tissues uses metabolomics and lipidomics to measure the relative polar and non-polar (lipid) metabolite levels in biological samples. This approach aims to understand disease biochemistry and identify biochemical markers of disease. Sample preparation methods must be repr...

2020-09-28 | MTBLS1707 | MetaboLights
MetabolomicsThe impact of nutritional supplementation on sweat metabolomic content
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
2021-03-15 | MTBLS2427 | MetaboLights
MetabolomicsAssessment of human plasma and urine sample preparation for re-producible and high-throughput UHPLC-MS clinical metabolic phenotyping

Clinical metabolic phenotyping employs metabolomics and lipidomics to detect and measure thousands of metabolites and lipids within human samples. This approach aims to identify metabolite and lipid changes between phenotypes (e.g. disease status) that aid understanding of biochemical mechanisms ...

2020-08-06 | MTBLS1465 | MetaboLights
UnknownNUMT Confounding Biases Mitochondrial Heteroplasmy Calls in Favor of the Reference Allele.
Not available
S-EPMC6773831 | biostudies-literature
UnknownEfficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia.
Not available
S-EPMC8911345 | biostudies-literature
UnknownIdeal cardiovascular health in urban Jamaica: prevalence estimates and relationship to community property value, household assets and educational attainment: a cross-sectional study.
Not available
S-EPMC7745314 | biostudies-literature
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