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TranscriptomicsDengue virus inhibits immune responses in Aedes aegypti cells
The ability of many viruses to manipulate the host antiviral immune response often results in complex host-pathogen interactions. In order to study the interaction of dengue virus (DENV) with the Aedes aegypti immune response, we have characterized the DENV infection-responsive transcriptome of the ...
ORGANISM(S): Aedes aegypti 
2011-10-31 | E-GEOD-33274 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq and scTCRseq of human CD8 T cells from blood and skin compartments in Dengue patients
Using a skin-blister induction model established for dengue, we investigated the transcriptional signatures and TCR repertoire of matched CD8 T cells in skin and blood samples
ORGANISM(S): Homo sapiens 
2026-04-14 | E-MTAB-16332 | biostudies-arrayexpress
TranscriptomicsDengue VN Microarray MD and DF study
DNA microarrays and specific RT-PCR assays were used to reveal transcriptional patterns in the blood of children presenting with dengue shock syndrome (DSS) and well-matched patients with uncomplicated dengue. The transcriptome of patients with acute uncomplicated dengue was characterized by a metab...
ORGANISM(S): Homo sapiens 
2008-12-18 | E-GEOD-13052 | biostudies-arrayexpress
TranscriptomicsMOYO-S and MOYO-R responsive genes to dengue-2 infection at 3hr and 18hr post-infection times
We conducted a genome-wide survey of genes in Ae. aegypti females that are transcriptionally responsive upon challenge with dengue virus (serotype-2). The array was designed with 60-mer oligos specific to 16,092 gene transcripts of gene build AaegL1.1 (www. vectorbase.org). The hybridizations were p...
ORGANISM(S): Aedes aegypti 
2011-09-29 | E-GEOD-16563 | biostudies-arrayexpress
TranscriptomicsDengue patients whole blood
Whole blood RNA (PAXgene tubes) was collected from 14 Dengue patients after hospital admission. Additional samples were collected at later time points from 6 of the patients, and single samples were also collected from 4 healthy donors. RNA was amplified using the MessageAmp kit (Ambion), and reve...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-40628 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Expression Profiling Deciphers Host Responses Altered during Dengue Shock Syndrome and Reveals the Role of Innate Immunity in Severe Dengue
Background Deciphering host responses contributing to dengue shock syndrome (DSS), the life-threatening form of acute viral dengue infections, is required to improve both the differential prognosis and the treatments provided to DSS patients, a challenge for clinicians. Methodology/Principal Findin...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-17924 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to dengue infection in peripheral blood mononuclear cells of Nicaraguan children
We measured fever-day-specific genome-wide transcript abundance patterns in 105 peripheral blood mononuclear cell (PBMC) samples collected from 41 children hospitalized with dengue virus (DENV) infection in Nicaragua, and from 8 healthy controls. DF1 = primary DF; DF2 = secondary DF; DHF = Dengue H...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-38246 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of human peripheral blood mononuclear cells (PBMCs) throughout the febrile, critical, and convalescence phases of dengue virus infection
We investigated the abundances and transcriptomic changes of immune cells at several time points over the course of dengue virus infection. The PBMC samples were obtained from one dengue fever (DF) and one dengue hemorrhagic fever (DHF) patients (8 samples in total). The samples were harvested at tw...
ORGANISM(S): Homo sapiens 
2022-02-16 | E-MTAB-9467 | biostudies-arrayexpress
TranscriptomicsInduction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following infection with dengue virus
Dengue viruses (DENV) are generally maintained in a cycle which requires horizontal transmission via their arthropod vector, Ae. Aegypti, to the vertebrate host. One important consequence of this process is the interference of these arboviruses with both invertebrate and vertebrate immune systems. W...
ORGANISM(S): Aedes aegypti 
2011-03-21 | E-GEOD-21528 | biostudies-arrayexpress
TranscriptomicsRNA-seq for dengue seronegative and dengue seropositive individuals from Singapore
RNA was extracted from whole blood of subjects collected in Tempus tubes. We performed gene expression analysis of dengue seropositive versus dengue seronegative subjects from Singapore.
ORGANISM(S): Homo sapiens 
2025-09-08 | E-MTAB-14343 | biostudies-arrayexpress
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