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MetabolomicsJ-Resolved 1H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis
1H nuclear magnetic resonance (NMR) spectroscopy-based metabolic phenotyping is now widely used for large-scale epidemiological applications. To minimize signal overlap present in 1D 1H NMR spectra, we have investigated the use of 2D J-resolved (JRES) 1H NMR spectroscopy for large-scale phenotyping ...
2018-07-23 | MTBLS540 | MetaboLights
UnknownPatterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry.

Background

Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospectiv...
S-EPMC10518516 | biostudies-literature
UnknownMechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.
The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a heterotetrameric complex (the "Bloom syndrome complex") for dissolution of double Holliday junctions, key intermediates in homologous recombination. Mutations in any component of the Bloom syndrome complex can cause g...
S-EPMC8832983 | biostudies-literature
UnknownValidating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry.
The 2MACE score was specifically developed as a risk-stratification tool in atrial fibrillation (AF) to predict cardiovascular outcomes. We evaluated the predictive ability of the 2MACE score in the GLORIA-AF registry. All eligible patients from phase II/III of the prospective global GLORIA-AF regis...
S-EPMC10830583 | biostudies-literature
Genomicsena-DATASET-RTL-10-04-2014-14:57:02:227-16 - samples
Fernandez-Cuesta et al, 2014, Nature Communication, Whole exome sequencing data set
EGAD00001000820 | EGA
Genomicsena-DATASET-RTL-03-04-2014-12:58:19:275-109 - samples
Fernandez-Cuesta et al., 2014, Nature Communication, Whole genome sequencing was performed using a read length of 2x100 bp for all samples. On average, 110 Gb of sequence were produced per sample, aiming a mean coverage of 30x for both tumour and matched normal.
EGAD00001000813 | EGA
GenomicsCA_SNP_6.0 - samples
SNP 6.0 arrays of carcinoid samples
EGAD00010000546 | EGA
Genomicsena-DATASET-RTL-26-03-2014-08:44:34:042-926 - samples
Fernandez-Cuesta et al, 2014, Nature Communication, RNA Sequencing data set
EGAD00001000795 | EGA
GenomicsFrequent mutations in chromatin-remodelling genes in pulmonary carcinoids
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n¼54), genome/exome (n¼44) and transcriptome (n¼69) sequencing of pulmonary...
EGAS00001000650 | EGA
UnknownImmune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma.

Objective

Current strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following neoadjuvant chemotherapy in OAC.

Design

Transcriptional profili...
S-EPMC6839732 | biostudies-literature
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