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MetabolomicsOceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges
Marine sponges (phylum Porifera) are leading organisms for the discovery of bioactive compounds from nature. Their often rich and species-specific microbiota is hypothesised to be producing many of these compounds. Yet, environmental influences on the sponge-associated microbiota and bioactive compo...
2023-05-12 | MTBLS1388 | MetaboLights
ProteomicsTargeting ERAP enhances anti-tumor immunity by disrupting the NKG2A/HLA-E inhibitory checkpoint
New targets that enhance anti-tumor immunity must be identified to improve the efficacy of cancer immunotherapy. Here we show that loss of endoplasmic reticulum aminopeptidase (ERAP) family proteins improves anti-tumor immunity and synergizes with immune checkpoint blockade. Mechanistically, we show...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD052031 | Pride
Human Hla-e Orbitrap Immunotherapy 
TranscriptomicsTranscription profiling of Drosophila developmental time series
Michelle N. Arbeitman, Eileen E. M. Furlong, Farhad Imam, Eric Johnson, Brian H. Null, Bruce S. Baker, Mark A. Krasnow, Matthew P. Scott, Ronald W. Davis and Kevin P. White. Gene Expression During the Life Cycle of Drosophila melanogaster, Science, 297: 2270-2275, 2002. This work can be accessed fro...
ORGANISM(S): Drosophila melanogaster 
2004-11-06 | E-FLYC-6 | biostudies-arrayexpress
ProteomicsHuman milk and gastric peptidomics
It is unclear to what degree protein degradation occurs in the infant stomach and whether peptides previously annotated for bioactivity are released. This study combined nanospray liquid chromatography separation with time of flight mass spectrometry, comprehensive structural libraries and informati...
ORGANISM(S): Homo sapiens (Human) 
2014-04-15 | PXD000688 | Pride
Peptidomics Human milk 
MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
UnknownRNase H1 levels dramatically affect mitochondrial genome maintenance with little impact on nuclear R-loops in murine B cells.
Not available
S-EPMC12190172 | biostudies-literature
UnknownRe-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications.
Not available
S-EPMC3317354 | biostudies-literature
MetabolomicsIdentification of pre-diagnostic lipid sets associated with liver cancer risk using untargeted lipidomics and chemical set analysis – a nested case-control study within the ATBC cohort

In pre-disposed individuals, a reprogramming of the hepatic lipid metabolism may support liver cancer initiation. We conducted a high-resolution mass spectrometry based untargeted lipidomics analysis of pre-diagnostic serum samples from a nested case-control study (219 liver cancer cases and 219 ...

2023-09-18 | MTBLS7776 | MetaboLights
UnknownIdentifying avian malaria vectors: sampling methods influence outcomes.
Not available
S-EPMC4702297 | biostudies-literature
UnknownContributions of the international plant science community to the fight against infectious diseases in humans-part 2: Affordable drugs in edible plants for endemic and re-emerging diseases.
Not available
S-EPMC8486237 | biostudies-literature
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