Sort   by:  
 Page size 
ProteomicsTargeting ERAP enhances anti-tumor immunity by disrupting the NKG2A/HLA-E inhibitory checkpoint
New targets that enhance anti-tumor immunity must be identified to improve the efficacy of cancer immunotherapy. Here we show that loss of endoplasmic reticulum aminopeptidase (ERAP) family proteins improves anti-tumor immunity and synergizes with immune checkpoint blockade. Mechanistically, we show...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD052031 | Pride
Human Hla-e Orbitrap Immunotherapy 
ProteomicsHLA-E Presents Glycopeptides from the Mtb Protein MPT32 to Human CD8 T Cells
Infection with Mycobacterium tuberculosis (Mtb), the bacterium that causes Tuberculosis, remains a global health concern. Both classically and non-classically restricted cytotoxic CD8+ T cells are important to the control of Mtb infection. We and others have demonstrated that the non-classical MHC I...
ORGANISM(S): Mycobacterium tuberculosis 
2018-10-26 | PXD005765 | Pride
Mycobacterium tuberculosis Cd8 t cells Hla-e 
GenomicsTGS of HLA-E gene
TGS of HLA-E gene
PRJEB40920 | ENA
ProteomicsA cytoplasmic tail motif directs HLA-E to clathrin-mediated endocytosis and valosin-containing-protein-mediated recycling
Recent discoveries highlight the effectiveness of major histocompatibility complex (MHC)-E-restricted CD8+ T cell responses in controlling certain infections, particularly in a rhesus cytomegalovirus (RhCMV68-1)-vectored simian immunodeficiency virus (SIV) vaccine. In this context, these responses a...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD060886 | Pride
Proximity labelling Hla-e 
TranscriptomicsSingle cell RNA-seq of HLA-E restricted UL40-specific T cells
Human cytomegalovirus infection (CMV) can stimulate robust human leukocyte antigen (HLA)-E restricted CD8 T cell responses. These T cells recognize a peptide from UL40, which differs by as little as a single methyl group from self-peptides that also bind HLA-E, challenging their capacity to avoid se...
ORGANISM(S): Homo sapiens 
2021-05-21 | E-MTAB-10305 | biostudies-arrayexpress
GenomicsMtb HLA-E tetramer sorted CD8+ T-cells have a diverse TCR repertoire
Mtb HLA-E tetramer sorted CD8+ T-cells have a diverse TCR repertoire
PRJNA989142 | ENA
GenomicsSingle cell RNA-seq of HLA-E restricted UL40-specific T cells
Single cell RNA-seq of HLA-E restricted UL40-specific T cells
PRJEB44340 | ENA
TranscriptomicsMtb HLA-E tetramer sorted CD8+ T-cells have a diverse TCR repertoire
HLA-E molecules can present self and pathogen-derived peptides to both NK-cells and T-cells. T-cells that recognize HLA-E peptides via their T-cell receptor (TCR) are termed donor-unrestricted T-cells due to restricted allelic variation of HLA-E. The composition and repertoire of HLA-E TCRs is not k...
ORGANISM(S): Homo sapiens 
2024-02-04 | GSE236154 | GEO
GenomicsHLA-E regulation of NK cell response in SARS-CoV-2 infection
HLA-E regulation of NK cell response in SARS-CoV-2 infection
PRJEB59036 | ENA
TranscriptomicsCD8 T cells cross-restricted by HLA-B*57 and HLA-E*01 recognize HIV Gag with different functional profiles [dataset 2]
Few non-classical HLA-E restricted HIV-specific epitopes have been described, and even less is known about the functional profile of responding CD8 T cells (CD8s). This study evaluates the functional characteristics of CD8s targeting the Gag epitope (KAFSPEVIPMF or KF11) based on their restriction b...
ORGANISM(S): Homo sapiens 
2025-12-11 | GSE306023 | GEO
Sort   by:  
 Page size