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TranscriptomicsMutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with renal clear cell carcinomas.
Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that regulate a diverse array of biological activities, including metabolism, homeostasis, and development. TRs also serve as tumor suppressors, and aberrant TR function (via mutation, deletion, or altered expression) is as...
ORGANISM(S): Homo sapiens 
2011-05-10 | E-GEOD-29159 | biostudies-arrayexpress
TranscriptomicsExpression profiling comparisons of human PBMC treated with class I/IIb or class IIa HDAC inhibitors
The aim of this study was to identify differential gene expression resulting from the inhibition of class IIa HDACs in human PBMC. Human PBMC were cultured ex vivo with a mitogenic stimulus (1 ug/ml phytohemagglutinin, PHA) for 60 hours concurrent with exposure to vehicle (DMSO), vorinostat (3 uM), ...
ORGANISM(S): Homo sapiens 
2013-03-24 | E-GEOD-44621 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Saccharomyces cerevisiae exposed to Tripelennamine in time course.
This study newly identified Tripelennamine (TA) as an inhibitor of yeast meiosis and sporulation. To examine if and how exposure of sporulating yeast cells to TA changes the meiotic transcriptional program cells were sporulated for 0, 4, and 8 hours in the presence or absence of 100 uM TA.
ORGANISM(S): Saccharomyces cerevisiae 
2010-03-31 | E-MEXP-2522 | biostudies-arrayexpress
UnknownTranscriptome profiling of equine vitamin E deficient neuroaxonal dystrophy identifies upregulation of liver X receptor target genes.
Not available
S-EPMC5154892 | biostudies-literature
TranscriptomicsTranscription profiling of Tripelennamine-treated sporulating yeast cells
This study newly identified Tripelennamine (TA) as an inhibitor of yeast meiosis and sporulation. To examine if and how exposure of sporulating yeast cells to TA influences the viability of the cells a homozygous deletion pool experiment was conducted.
ORGANISM(S): Saccharomyces cerevisiae 
2010-03-31 | E-MEXP-2535 | biostudies-arrayexpress
UnknownProbabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma.
Not available
S-EPMC6580486 | biostudies-literature
UnknownThe impact of structural variation on human gene expression.
Not available
S-EPMC5406250 | biostudies-literature
UnknownImproving Hepatocellular Carcinoma Surveillance Outcomes in Patients with Cirrhosis after Hepatitis C Cure: A Modelling Study.
Not available
S-EPMC11312194 | biostudies-literature
UnknownInapparent infections shape the transmission heterogeneity of dengue.
Not available
S-EPMC10003742 | biostudies-literature
UnknownValproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models.
Not available
S-EPMC11835743 | biostudies-literature
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