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TranscriptomicsGene expression profiles of Tet1 knockout (T1KO), Tet2 knockout (T2KO) and Tet1/Tet2 double knockout (DKO) mouse embryonic stem cells.
Global gene expression profile of single and double mutant mouse ES cells were compared to wt ES cells. Two male Tet1 KO, one male Tet2 KO, two male double KO, two female double KO, two male WT and two female WT mouse ES cells were compared. Global gene expression profile of single and double knocko...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-42991 | biostudies-arrayexpress
GenomicsLoss of Tet enzymes compromises proper differentiation of embryonic stem cells
Tet enzymes (Tet1/2/3) catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and are dynamically expressed in various embryonic and adult cell types. While loss of individual Tet enzymes or combined deficiency of Tet1/2 allows for embryogenesis, the effect of complete ...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-55049 | biostudies-arrayexpress
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