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TranscriptomicsTranscriptomic profiling of antigen-specific T cells at the single-cell level after clearance of hepatitis C virus
We used scRNA-seq data generated using Smart-seq2 to reconstruct the native TCR from Ag-specific T cells and then to link these with the gene expression profile of individual cells. antigen specific CD8 T cells were obtained from a subject who had previously cleared hepatitis C virus (HCV) infection...
ORGANISM(S): Homo sapiens 
2017-01-31 | E-MTAB-4850 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Schistosoma mansoni larval development using serial analysis of gene expression (SAGE)
Biomphalaria glabrata infection by the Schistosoma mansoni free-swimming miracidium and its subsequent development to the parasitic sporocyst stage is critical to establishment of viable infections and triggers a variety of physiological, biochemical and molecular changes. Here, we describe a genom...
ORGANISM(S): Schistosoma mansoni 
2009-03-09 | E-GEOD-9722 | biostudies-arrayexpress
GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
TranscriptomicsProfiling of differential allelic expression in mouse placenta from reciprocal crosses
Many questions about the regulation, functional specialization, computational prediction, and evolution of genomic imprinting would be better addressed by having an exhaustive genome-wide catalog of genes that display parent-of-origin differential expression. As a first-pass scan for novel imprinte...
ORGANISM(S): Mus musculus 
2011-06-15 | E-GEOD-29690 | biostudies-arrayexpress
UnknownAlcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study.
Not available
S-EPMC6662590 | biostudies-literature
TranscriptomicsTranscription profiling of liver from hypothyroid mice pups produced from dams given 6-propyl-2-thiouracil (PTU) in their drinking water
Pregnant dams were treated with 0.1% or 0.04% 6-propyl-2-thiouracil (PTU) in drinking water continuously from day 13 post conception until weaning to produce hypothyroid pups. livers were collected from vehicle and 0.1% PTU treated pups at post-natal day (PND) 15 and mRNA from these was subjected to...
ORGANISM(S): Mus musculus 
2007-05-03 | E-MEXP-1091 | biostudies-arrayexpress
UnknownAlcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study.
Not available
S-EPMC5356930 | biostudies-literature
TranscriptomicsTranscription profiling of mouse bipotential embryonic liver cells to identify liver progenitor cell surface markers (430)
The ability to purify to homogeneity a population of hepatic progenitor cells from adult liver is critical for their characterization prior to any therapeutic application. As a step in this direction, we have utilized gene profiling of a bipotential liver cell line from dpc 14 mouse embryonic liver...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6957 | biostudies-arrayexpress
ProteomicsQuantification of HER2 by Immunopeptide Enrichment and Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) and Frozen Breast Cancer Tissues
Background: Conventional HER2-targeting therapies improve outcomes for patients with HER2-positive breast cancer (BC), defined as tumors showing HER2 protein overexpression by an immunohistochemistry (IHC) assay and/or ERBB2 gene amplification determined by in situ hybridization (ISH). Emerging HER2...
ORGANISM(S): Homo Sapiens 
2021-07-07 | PXD021893 | panorama
ProteomicsPrion MRM assay development and clinical study
Therapies currently in preclinical development for prion disease seek to lower prion protein (PrP) expression in the brain. Trials of such therapies are likely to rely on quantification of PrP in cerebrospinal fluid (CSF) as a pharmacodynamic biomarker and possibly as a trial endpoint. Studies using...
ORGANISM(S): Homo Sapiens Rattus Norvegicus Mus Musculus Macaca Fascicularis 
2019-11-19 | PXD014781 | panorama
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