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GenomicsTranscriptomic analyis of donor (B6:SJL.C20) and host follicular and marginal zone B cells after adoptive transfer of follicular B cells into into lymphopenic (Rag2-/-) or replete animals (C57BL6)
Transcriptomic analyis of donor (B6:SJL.C20) and host follicular and marginal zone B cells after adoptive transfer of follicular B cells into into lymphopenic (Rag2-/-) or replete animals (C57BL6)
PRJNA823704 | ENA
MetabolomicsGut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia
Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral and central nervous systems. FD is monogenic, with >99.4% of patients sharing an identical point mutation in the elongator acetyltransferase co...
2022-12-06 | MTBLS5138 | MetaboLights
TranscriptomicsTranscription profiling of mouse atrioventricular junction gene expression at embryonic day 10.5-11.0
Goals of this study were to identify new candidates involved in the development of the Atrioventricular cushions in the mouse heart. Experiment Overall Design: The atrioventricular junction and ventricular region were dissected from 80 embryonic day 10.5-11.0, wild type, C57BL/6 mouse hearts. RNA w...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4903 | biostudies-arrayexpress
UnknownGerminal Center B Cell and T Follicular Helper Cell Responses to Viral Vector and Protein-in-Adjuvant Vaccines.
Not available
S-EPMC4974488 | biostudies-literature
TranscriptomicsTranscription profiling of mouse spleen from animals exposed to Ebola virus reveals reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection
To gain insight into the changes in gene expression pattern upon Ebola infection, CD45+/+ (100% protein level) and CD45+/- (62% protein level) mice were challenged with mouse adapted Ebola virus. At time-points day 0, 1, 3, 5, 7, 9, 11 and 13, spleen tissue was harvested and splenocytes isolated. To...
ORGANISM(S): Mus musculus 
2009-09-05 | E-GEOD-17509 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat testis by transplacental exposure to estrogen receptor (ER) agonists - high and low doses of 17a-Ethynyl estradiol, genistein or bisphenol A
The purpose of this study was to determine 1) the transcriptional program elicited by exposure to three estrogen receptor (ER) agonists: 17 a-ethynyl estradiol (EE), genistein (Ges) and bisphenol A (BPA) during fetal development of the rat testis and epididymis; and 2) whether very low dosages of es...
ORGANISM(S): Rattus norvegicus 
2005-05-18 | E-TABM-12 | biostudies-arrayexpress
UnknownThe Effect of Breakfast Prior to Morning Exercise on Cognitive Performance, Mood and Appetite Later in the Day in Habitually Active Women.
Not available
S-EPMC4517027 | biostudies-literature
TranscriptomicsTranscription profiling of differentiating mouse embryonic fibroblasts generated from wild type and PKBa-/- mice to study the role of PKBa in adipose differentiation.
Mouse embryonic fibroblasts (MEFs) were generated from 13.5-day-old embryos obtained from heterozygous PKBa mice intercrosses (Yang et al., 2003). Briefly, after dissection of head and visceral organs for genotyping, embryos were minced and trypsinized for 30 min at 37°C. Embryonic fibroblasts were ...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2746 | biostudies-arrayexpress
TranscriptomicsSex-biased expression in heads of three Drosophila species
Investigation of sex-biased expression across species have relied on measurements from whole flies which sample the extensive expression differences found in the germline and gonads of females and males. We wanted to examine genes with sex-biased expression in a somatic tissue to analyze patterns of...
ORGANISM(S): Drosophila pseudoobscura 
2010-07-30 | E-GEOD-23309 | biostudies-arrayexpress
ProteomicsInhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression
We employed a guinea pig model of heart failure (HF) that combines ascending aortic constriction with daily administration of the β-adrenergic agonist isoproterenol (1 mg/kg/day for 1 hour) via an implanted programmable pump. The experimental groups included: 1) Sham-operated controls; 2) ACi (Aorti...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-09-08 | PXD058012 | Pride
Heart failure Guinea pig Heart P38 inhibition Tmt Lc-ms/ms 
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