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TranscriptomicsIdentification of genes associated with lens regeneration from the cornea in Xenopus laevis tadpoles
Surgical removal of the lens from larval Xenopus laevis results in a rapid transdifferention of central corneal cells to form a new lens. The trigger for this process is understood to be an induction event arising from the unprecedented contact between the cornea and the vitreous humour that occurs ...
ORGANISM(S): Xenopus laevis 
2011-09-13 | E-GEOD-28014 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [Micro-C]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15688 | biostudies-arrayexpress
TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-41170 | biostudies-arrayexpress
Transcriptomicsgonad-only_young_adult_20dC_42hrs_post-L1_N2_tiling_array
modENCODE_submission_481 This submission comes from a modENCODE project of Robert Waterston. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: Our experiments are designed to detect all C. elegans transcripts by hybridizing RNA to commerically available genome til...
ORGANISM(S): Caenorhabditis elegans 
2010-08-04 | E-GEOD-23269 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and A-C/EBP transgenic mouse embryonic fibroblasts during adipogenesis to identify C/ebp alpha target genes
This experiment was designed to identify C/ebp alpha target genes during the process of adipogenesis by means of comparison of differentiating (wild-type) cells to a perturbation model (transgenic cells). For this, gene expression profiling during adipogenesis of mouse embryonic fibroblasts (MEFs) ...
ORGANISM(S): Mus musculus 
2009-07-02 | E-MARS-11 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tumours at baseline and after 21 days of treatment with sorafenib and dacarbazine
Background New approaches are needed to improve prognostic accuracy for treatment response and to explore the complexities of drug effects on human tumours. We developed a strategy of global genomic investigation of sequential tumor biopsies at baseline and 21 days post-treatment, and applied this ...
ORGANISM(S): Homo sapiens 
2010-07-31 | E-TABM-760 | biostudies-arrayexpress
UnknownDoxepin rinse versus placebo in the treatment of acute oral mucositis pain in patients receiving head and neck radiotherapy with or without chemotherapy: a phase III, randomized, double-blind trial (NCCTG-N09C6 [Alliance]).
Not available
S-EPMC4026580 | biostudies-literature
TranscriptomicsTranscriptional profiling of dentate granule cells in 4 rat epilepsy models
Global expression profiling of epileptogenesis has been confounded by variability across laboratories, epilepsy models, tissue sampled and experimental platforms, with the result that very few genes demonstrate consistent expression changes. The present study minimizes these confounds by combining ...
ORGANISM(S): Rattus norvegicus 
2013-06-08 | E-GEOD-47752 | biostudies-arrayexpress
UnknownPhase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status.
Not available
S-EPMC3804291 | biostudies-literature
TranscriptomicsLeukemia Inhibitory Factor in C26 Cancer Cachexia
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer. C2C12 myotubes treated with conditioned mediu...
ORGANISM(S): Mus musculus 
2015-06-25 | E-GEOD-68827 | biostudies-arrayexpress
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