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TranscriptomicsDiet-Induced Obesity Reprograms the Inflammatory Response of the Murine Lung to Inhaled Endotoxin
To identify key biological pathways that define susceptibility factors for pulmonary infection during obesity, diet-induced obese (DIO) and regular weight (RW) C57BL/6 mice were exposed to 0.5 M-BM-5g/L inhaled lipopolysaccharide (LPS) for 1 hr/d for 4 days over a period of 2 weeks. Transcriptional ...
ORGANISM(S): Mus musculus 
2012-09-15 | E-GEOD-38092 | biostudies-arrayexpress
TranscriptomicsDiet-Induced Obesity Exacerbates Inflammatory and Oxidative Stress Responses in Mice Exposed to Cigarette Smoke
To identify biosignatures that describe these lifestyle susceptibility factors, we performed parallel exposures of regular weight (RW) C57BL/6 and diet-induced obese (DIO) C57BL/6 mice to cigarette smoke, either mainstream (MS) or sidestream (SS), mimicking both the smoker and environmental exposure...
ORGANISM(S): Mus musculus 
2012-09-15 | E-GEOD-38093 | biostudies-arrayexpress
TranscriptomicsImpaired Transcriptional Response of the Murine Heart To Cigarette Smoke in the Setting of High Fat Diet and Obesity
To identify biosignatures that describe these lifestyle susceptibility factors, we performed parallel exposures of regular weight (RW) C57BL/6 and diet-induced obese (DIO) C57BL/6 mice to cigarette smoke, either mainstream (MS) or sidestream (SS), mimicking both the smoker and environmental exposure...
ORGANISM(S): Mus musculus 
2013-05-17 | E-GEOD-47022 | biostudies-arrayexpress
MetabolomicsGut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia
Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral and central nervous systems. FD is monogenic, with >99.4% of patients sharing an identical point mutation in the elongator acetyltransferase co...
2022-12-06 | MTBLS5138 | MetaboLights
TranscriptomicsGene expression profile of control and CRISPR-edited MATN3 V194D mutant Day 21 cartilage pellets differentiated from the human ESC line MAN13
RNA-seq of control and MATN3 V194D mutant cartilage pellets. The MATN3 V194D mutation was introduced using CRISPR-Cas9 in pluripotent cells before differentiation through an iMSC intermediate to Day 21 cartilage pellets.
ORGANISM(S): Homo sapiens 
2026-02-12 | E-MTAB-16599 | biostudies-arrayexpress
TranscriptomicsLeukemia Inhibitory Factor in C26 Cancer Cachexia
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer. C2C12 myotubes treated with conditioned mediu...
ORGANISM(S): Mus musculus 
2015-06-25 | E-GEOD-68827 | biostudies-arrayexpress
UnknownBreakthrough SARS-CoV-2 infections among patients with cancer following two and three doses of COVID-19 mRNA vaccines: a retrospective observational study from the COVID-19 and Cancer Consortium.
Not available
S-EPMC9925160 | biostudies-literature
TranscriptomicsTranscription profiling of FACS sorted mouse calvarial osteroblasts at defined differentiation stages to identify genes highly associated with osteoblast differentiation
This study compares a comprehensive microarray analysis of unsorted mCOB cultures at two level of cell differentiation with cells that are more homogeneous for a level of cellular differentiation. It demonstrates the loss of information and in some cases misinformation that occurs when a heterogeneo...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2332 | biostudies-arrayexpress
MetabolomicsIntegrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: the crucial role of lipid metabolism
Pandemic influenza viruses modulate pro-inflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Int...
2016-05-11 | MTBLS196 | MetaboLights
TranscriptomicsRNA-seq of wild-type, Mbd3 and Sall4/1 mutant mouse embryonic stem cells
Mouse embryonic stem cells mutant for Mbd3, Sall4 and/or the related Sall1 pluripotency-associated factors were cultured in self-renewing and neural differentiation conditions and profiled by RNA-seq.
ORGANISM(S): Mus musculus 
2016-08-09 | E-MTAB-4566 | biostudies-arrayexpress
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