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TranscriptomicsCLIP-seq of S. cerevisiae Drn1-TAP and Dbr1-TAP
Data for replicate Drn1-TAP and Dbr1-TAP CLIP-seq experiments to identify RNA-protein interactions Drn1-TAP and Dbr1-TAP CLIP-seq
ORGANISM(S): Saccharomyces cerevisiae 
2013-06-28 | E-GEOD-44959 | biostudies-arrayexpress
GenomicsLariat mapping of DBR1 KO and DBR1 KO+DBR1 addback cells
Lariat mapping of DBR1 KO and DBR1 KO+DBR1 addback cells
PRJNA800759 | ENA
ProteomicsDBR1 Interactors Identification Mass Spectrometry Analysis
DBR1 interactors were identified from HeLa-S cells.
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD042580 | Pride
Lc-msms Hela-s 
TranscriptomicsLariat mapping of DBR1 KO and DBR1 KO+DBR1 addback cells
We constructed a DBR1 knockout cell line (C22) using CRISPR in HEK293T cells. Through mapping of lariat reads, lariat levels in the DBR1 - samples are shown to increase dramatically (~20x) relative to wild type cells. Over 60% of this increase in lariat levels is abrogated upon rescue of DBR1 - cell...
ORGANISM(S): Homo sapiens 
2022-01-29 | GSE195469 | GEO
ProteomicsDBR1 Interactors Identification Analysis in TTDN1 KO background
DBR1 interactors were identified from HeLa-S cells (WT or TTDN1 KO).
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD042563 | Pride
Lc-msms Hela-s 
ProteomicsThe Debranching Enzyme Dbr1 Regulates Lariat Turnover and Intron Splicing
The majority of genic transcription is intronic. Introns are removed by splicing as branched lariat RNAs which require rapid recycling. The branch site is recognized during splicing catalysis and later debranched by Dbr1 in the rate-limiting step of lariat turnover. Through generation of the first v...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-26 | MSV000092263 | MassIVE
GenomicsLariat mapping of a DBR1 CRISPR KO cell line
Lariat mapping of a DBR1 CRISPR KO cell line
PRJNA801289 | ENA
GenomicsDebranching enzyme DBR1-mediated lariat RNA turnover requires ALBA proteins in Arabidopsis
Debranching enzyme DBR1-mediated lariat RNA turnover requires ALBA proteins in Arabidopsis
PRJNA1200608 | ENA
TranscriptomicsDebranching enzyme DBR1-mediated lariat RNA turnover requires ALBA proteins in Arabidopsis
Lariat RNAs, generated as by-products of RNA splicing from excised introns, must be removed. RNA debranching enzyme (DBR1) is the core factor responsible for lariat RNA removal. However, the mechanism by which DBR1 debranches lariat RNAs remains unclear. Here, we demonstrate that six ALBA (Acetylati...
ORGANISM(S): Arabidopsis thaliana 
2025-11-20 | GSE284756 | GEO
UnknownSARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency.
Not available
S-EPMC11256911 | biostudies-literature
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