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ProteomicsDDHD2, whose mutation causes spastic paraplegia type 54, is cargo receptor for lipophagy
DDHD2 mutation was a common cause of SPG54 disease. While its mechanism of action was unclear, we aimed to comprehensively characterize the DDHD2 interactome networks in cells. To achieve this, we used affinity purification coupled with mass spectrometry (AP-MS) to define the interactome for DDHD2. ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044430 | Pride
Lipophage Ddhd2 Spg54 
UnknownBiallelic DDHD2 mutations in patients with adult-onset complex hereditary spastic paraplegia.
Not available
S-EPMC10502669 | biostudies-literature
UnknownDDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains.
Not available
S-EPMC12485780 | biostudies-literature
UnknownThe hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase.
Not available
S-EPMC4205627 | biostudies-literature
UnknownLoss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis.
Not available
S-EPMC6056544 | biostudies-literature
UnknownDDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins.
Not available
S-EPMC10923888 | biostudies-literature
UnknownDDHD2 provides a flux of saturated fatty acids for neuronal energy and function.
Not available
S-EPMC12552131 | biostudies-literature
UnknownFunctional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.
Not available
S-EPMC5854151 | biostudies-literature
ProteomicsDDHD2 interacts with STXBP1 to mediate long-term memory via the generation of saturated free fatty acidsDDHD2 interacts with STXBP1 to mediate long-term memory via the generation of saturated free fatty acids
The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning and memory, but the mechanisms through which neuronal activity affects the brain's lipid landscape remain largely unexplored. Saturated FFAs, particularly myristic acid (C14:0), strongly inc...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-22 | PXD047812 | Pride
Phospholipase a1  free fatty acids  myristic acid  learning and memory Lipids 
UnknownThe DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids.
Not available
S-EPMC10897203 | biostudies-literature
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